INT312888

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6)
intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)
Hdac6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 18 55.28 Quite High
Serotonin 18 27.68 Quite Low
fluoxetine 27 9.52 Low Low
sSRI 18 8.40 Low Low
imagery 45 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 126 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Infection 18 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, a genome-wide phosphoprotein survey has shown that this site on HDAC6 is phosphorylated [18].
Phosphorylation (phosphorylated) of HDAC6
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
may directly phosphorylate HDAC6 at this site, although further work with purified proteins is needed to determine whether this is the case.
Phosphorylation (phosphorylate) of HDAC6
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
The function of HDAC6 phosphorylation
Phosphorylation (phosphorylation) of HDAC6
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Using a phosphoepitope-specific antibody, we showed that phosphorylation of HDAC6 at serine-22, which conforms to the consensus site for GSK3?
Phosphorylation (phosphorylation) of HDAC6
4) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Using a commercially available antibody (Abcam, ab61058, HDAC6-phospho S22), we found that inhibiting GSK3?
Phosphorylation (phospho) of HDAC6
5) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.03
Various phosphorylation site prediction methods have indicated that serine-22 in murine and rat HDAC6 (corresponding to serine-21 in human HDAC6) may be phosphorylated by GSK3?.
Phosphorylation (phosphorylated) of HDAC6
6) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Using a phosphoepitope-specific antibody, we showed that phosphorylation of HDAC6 at serine-22, which conforms to the consensus site for GSK3?
Phosphorylation (phosphorylation) of HDAC6
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
It has been shown that HDAC6 is a phosphoprotein [18], [19], but neither the kinases that are responsible for phosphorylating HDAC6 nor the effect of phosphorylation on this deacetylase have been established.
Phosphorylation (phosphorylation) of HDAC6
8) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
It has been shown that HDAC6 is a phosphoprotein [18], [19], but neither the kinases that are responsible for phosphorylating HDAC6 nor the effect of phosphorylation on this deacetylase have been established.
Phosphorylation (phosphorylating) of HDAC6
9) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

General Comments

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