INT312930

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hes3) DNA binding (Hes3) transcription factor binding (Hes3)
Anatomy Link Frequency
nucleus 2
Hes3 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 10 100.00 Very High Very High Very High
Perioperative pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vibrio Infection 46 88.56 High High
Neurological Disease 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 4 5.00 Very Low Very Low Very Low
Post Operative Pain 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Glioblastoma 2 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream of Tie2 signaling is a pathway that induces Hes3 expression and regulates NSC survival [23].
Positive_regulation (induces) of Gene_expression (expression) of Hes3
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.15 Pain Relevance 0.04
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Positive_regulation (induced) of Gene_expression (found) of Hes3 in nucleus associated with withdrawal
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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