INT312930

Context Info Confidence 0.54 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.22 Pain Relevance 0.12

nucleus (Hes3) DNA binding (Hes3) transcription factor binding (Hes3)

Anatomy Link Frequency nucleus 2 Hes3 (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 10 100.00 Perioperative pain 4 5.00 imagery 4 5.00 cytokine 2 5.00 Central nervous system 2 5.00 anesthesia 2 5.00 isoflurane 2 5.00 Hippocampus 2 5.00

Disease Link Frequency Relevance Heat Vibrio Infection 46 88.56 Neurological Disease 6 5.00 Cancer 6 5.00 Disease 6 5.00 Stroke 6 5.00 Camurati-engelmann Disease 4 5.00 Post Operative Pain 4 5.00 Stress 4 5.00 Glioblastoma 2 5.00 Bordatella Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Downstream of Tie2 signaling is a pathway that induces Hes3 expression and regulates NSC survival [23].

Positive_regulation (induces) of Gene_expression (expression) of Hes3

1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.15 Pain Relevance 0.04

In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.

Positive_regulation (induced) of Gene_expression (found) of Hes3 in nucleus associated with withdrawal

2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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