INT312932

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.20
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hes3) DNA binding (Hes3) transcription factor binding (Hes3)
Anatomy Link Frequency
brain 1
adult brain 1
nucleus 1
stem cells 1
Hes3 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 35 99.94 Very High Very High Very High
Perioperative pain 14 55.68 Quite High
cytokine 7 54.12 Quite High
Central nervous system 7 43.48 Quite Low
imagery 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vibrio Infection 161 99.58 Very High Very High Very High
Neurological Disease 21 97.72 Very High Very High Very High
Cancer 21 97.40 Very High Very High Very High
Malignant Neoplastic Disease 7 96.80 Very High Very High Very High
Brain Tumor 7 96.40 Very High Very High Very High
Glioblastoma 7 96.16 Very High Very High Very High
Disease 21 91.24 High High
Stress 14 86.76 High High
Stroke 21 77.60 Quite High
Post Operative Pain 14 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uncovering novel treatments that will affect Hes3 expression and localization will be a new set of tools in regenerative and cancer medicine.


Gene_expression (expression) of Hes3 associated with cancer
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.76 Pain Relevance 0.06
Downstream of Tie2 signaling is a pathway that induces Hes3 expression and regulates NSC survival [23].
Gene_expression (expression) of Hes3
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.15 Pain Relevance 0.04
We have recently shown that fetal and adult rodent and primate NSCs in culture as well as a newly identified multipotent neural precursor in the adult brain express the angiopoietin receptor Tie2 and the transcription factor Hes3 [22], [25], [32], [33].
Gene_expression (express) of Hes3 in adult brain
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.23 Pain Relevance 0
Recently, we have also shown that the presence of Hes3 marks not only the normal endogenous NSC but also the stem cell compartment in malignant brain tumors [24].
Gene_expression (presence) of Hes3 in brain associated with malignant neoplastic disease and brain tumor
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.65 Pain Relevance 0
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Gene_expression (found) of Hes3 in nucleus associated with withdrawal
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.07 Pain Relevance 0.08
Our findings show that cholera toxin regulates the expression and localization of Tie2 and Hes3 and induces powerful expansion of cultured NSCs.


Gene_expression (expression) of Hes3 associated with vibrio infection
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.67 Pain Relevance 0.03
A key finding is that the localization of Hes3 correlates strongly with the proliferative state of stem cells: Quiescent endogenous stem cells throughout the adult brain exclude Hes3 from the nucleus but express it in the cytoplasm; when placed in culture under mitogenic support that promotes proliferation, Hes3 is found in both the cytoplasm and nucleus.
Gene_expression (exclude) of Hes3 in stem cells
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.68 Pain Relevance 0

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