INT3130

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.08
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
plasma 1
pituitary 1
central nervous system 1
ovary 1
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 12 99.80 Very High Very High Very High
antagonist 5 99.62 Very High Very High Very High
Opioid 4 99.40 Very High Very High Very High
noradrenaline 6 97.64 Very High Very High Very High
dopamine receptor 1 95.36 Very High Very High Very High
Central nervous system 1 94.36 High High
Analgesic 1 93.76 High High
anesthesia 5 93.68 High High
agonist 9 92.00 High High
Pain threshold 12 89.20 High High
Disease Link Frequency Relevance Heat
Cancer 10 98.40 Very High Very High Very High
Aids-related Complex 4 98.08 Very High Very High Very High
Prostate Cancer 3 95.08 Very High Very High Very High
Body Weight 14 92.88 High High
Pain 17 89.20 High High
Urological Neuroanatomy 1 89.04 High High
Carcinoma 1 82.72 Quite High
Stress 24 75.64 Quite High
Adenocarcinoma 1 75.20 Quite High
Reprotox - General 1 6 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LH beta-subunit mRNA (m = 29 +/- 1 pg cDNA bound/100 micrograms pituitary DNA) was unchanged throughout the day.
Neg (unchanged) Transcription (unchanged) of LH in pituitary
1) Confidence 0.67 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3337227 Disease Relevance 0 Pain Relevance 0.08
Furthermore, the opioid antagonist naloxone does not raise serum LH levels in either sex after long-term gonadectomy.
Neg (not) Transcription (raise) of LH associated with antagonist, narcan and opioid
2) Confidence 0.65 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2903898 Disease Relevance 0 Pain Relevance 0.90
In most experimental groups, LH responses after naloxone were clearly unrelated to pituitary LH responsiveness to LHRH, which indicates that the opioid antagonist was acting via the central nervous system.
Transcription (responses) of LH in central nervous system associated with antagonist, narcan, central nervous system and opioid
3) Confidence 0.59 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6368728 Disease Relevance 0 Pain Relevance 0.48
Conversely to the prolactin response, LH levels did not rise after 3 Hz stimulation of the POA-SQ region.
Neg (not) Transcription (rise) of LH
4) Confidence 0.59 Published 1978 Journal Brain Res. Section Abstract Doc Link 638765 Disease Relevance 0.37 Pain Relevance 0.24
Rats treated with either nalmefene or progesterone on pro-oestrus demonstrated similar advances in the time of initiation of the LH surge by 1-2 h compared with control rats.
Transcription (initiation) of LH
5) Confidence 0.53 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.20
The peak plasma LH levels after each NMDA injection and the cumulative LH responses were significantly higher in peptide-treated than in control rats.
Transcription (levels) of LH in plasma
6) Confidence 0.52 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827626 Disease Relevance 0 Pain Relevance 0.78
LH subunit mRNA concentrations during LH surge in ovariectomized estradiol-replaced rats.
Transcription (concentrations) of LH
7) Confidence 0.45 Published 1988 Journal Am. J. Physiol. Section Title Doc Link 3337227 Disease Relevance 0 Pain Relevance 0.07
NMDA rapidly releases LH and LHRH mRNA levels are significantly raised within 15 minutes and remain so over the next 45 minutes.
Transcription (raised) of LH
8) Confidence 0.35 Published 1992 Journal Ciba Found. Symp. Section Abstract Doc Link 1425026 Disease Relevance 0.09 Pain Relevance 0.74
Serum was collected at 40 hours after EB injection and 6 hours after the progesterone injection for the detection of LH levels with a kit from Diagnostic Systems Laboratories (Webster, Texas, USA).
Transcription (detection) of LH
9) Confidence 0.22 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.48 Pain Relevance 0.33
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Transcription (detected) of LH in ovary
10) Confidence 0.22 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.14 Pain Relevance 0
The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were detected by radioimmunoassay, and the expression of gonadotropin-releasing hormone (GnRH) mRNA in hypothalamus and ovary, GnRH receptor (GnRH-R) mRNA in pituitary, estrodiol receptor (ER) mRNA and progesterone receptor (PR) mRNA in uterus were determined using RT-PCR.
Transcription (detected) of LH in hypothalamus
11) Confidence 0.07 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.14 Pain Relevance 0
Serum LH, prolactin and testosterone levels in Copenhagen F-1 rats bearing Dunning tumors were significantly decreased after treatment with D-Trp6-LH-RH.
Transcription (levels) of Serum LH associated with cancer
12) Confidence 0.02 Published 1984 Journal Med Oncol Tumor Pharmacother Section Abstract Doc Link 6242477 Disease Relevance 0.87 Pain Relevance 0

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