INT31307

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh1) extracellular region (Ghrh, Gh1) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 1
Ghrh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 8 99.66 Very High Very High Very High
anesthesia 2 86.88 High High
Clonidine 3 77.80 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 20 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of somatostatin caused enhanced GH response to GRF and no increase in basal GH level with pre-treatment of antiserum against somatostatin.
GRF Regulation (response) of GH associated with somatostatin
1) Confidence 0.27 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.48
In conclusion, there is in the spontaneously diabetic rat an increased in vivo and in vitro GH responsiveness to exogenous hGRF suggesting an abnormality of GH regulation at the pituitary level.
hGRF Regulation (responsiveness) of GH in pituitary associated with diabetes mellitus
2) Confidence 0.08 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2888037 Disease Relevance 0.68 Pain Relevance 0.10
However, the GH response to hGRF was significantly greater in the diabetic group (GH increment 873 +/- 153 ng/ml) than in the control group (268 +/- 91 ng/ml).
hGRF Regulation (response) of GH associated with diabetes mellitus
3) Confidence 0.08 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2888037 Disease Relevance 0.68 Pain Relevance 0.11

General Comments

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