INT313101

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Carf) nucleolus (Carf) nucleus (Carf)
Anatomy Link Frequency
brains 4
cortex 2
Carf (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 4 89.16 High High
Thalamus 4 33.52 Quite Low
Eae 4 28.20 Quite Low
Glutamate receptor 4 13.12 Low Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 120 99.48 Very High Very High Very High
Cognitive Disorder 8 28.20 Quite Low
Anxiety Disorder 4 24.76 Low Low
Congenital Anomalies 4 19.80 Low Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It would be particularly interesting if CaRF were recruited to consensus and non-consensus binding sites through distinct mechanisms, as this would imply a potential means to differentially regulate the expression of subsets of CaRF target genes.
Regulation (regulate) of Gene_expression (expression) of CaRF
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
For evaluation of CaRF target gene expression, brains from single P0 pups from a Carf heterozygote (HET×HET) cross were removed, the cortex was dissected and rapidly frozen on liquid nitrogen, then the thawed tissue was used for RNA harvesting.
Regulation (evaluation) of Gene_expression (expression) of CaRF in cortex
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.06 Pain Relevance 0
Nonetheless, we have demonstrated that at least a subset of the putative CaRF target genes show altered expression in the brains of Carf KO mice, demonstrating that CaRF expression is important for their proper regulation.
Regulation (important) of Gene_expression (expression) of CaRF in brains associated with targeted disruption
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.23 Pain Relevance 0.04
Nonetheless, we have demonstrated that at least a subset of the putative CaRF target genes show altered expression in the brains of Carf KO mice, demonstrating that CaRF expression is important for their proper regulation.
Regulation (altered) of Gene_expression (expression) of CaRF in brains associated with targeted disruption
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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