INT313117

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Carf) protein binding, bridging (Stub1) enzyme binding (Stub1)
ligase activity (Stub1) cytoplasm (Stub1) protein folding (Stub1)
Anatomy Link Frequency
neuronal 2
neurons 1
Stub1 (Mus musculus)
Carf (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Calcium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 5 39.40 Quite Low
Targeted Disruption 150 23.60 Low Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an independent set of experiments, we identified a highly similar motif (the 10bp chCaRE) when we aligned the fragments of neuronal genomic DNA that specifically coimmunoprecipitated with CaRF by ChIP.
ChIP Binding (coimmunoprecipitated) of CaRF in neuronal
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
Whether CaRF may bind to other sequence motifs in these ChIP peaks or whether CaRF may bind these variant chCaRE motifs in collaboration with a binding partner remains unknown.
ChIP Binding (bind) of CaRF
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
These data raise the question of whether CaRF also directly associates with the other 35.5% of the ChIP peaks that contain base changes in key positions within the chCaRE motif, as well as those that lack a sequence with any similarity to the cCaRE.
ChIP Binding (associates) of CaRF
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
ChIP-Seq identifies genomic binding sites of CaRF in neurons
ChIP Binding (sites) of CaRF in neurons
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
Nonetheless, taken together these data provide strong evidence to suggest that the ChIP peaks represent sites of high affinity CaRF binding to neuronal genomic DNA in vivo.


ChIP Binding (binding) of CaRF in neuronal
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0

General Comments

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