INT313221

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.45
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Tec) plasma membrane (Tec) cytoskeleton (Tec)
kinase activity (Tec) cytoplasm (Tec)
Anatomy Link Frequency
Macrophages 1
tubules 1
T cells 1
neutrophils 1
Tec (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 324 68.08 Quite High
Analgesic 4 55.88 Quite High
ischemia 36 50.00 Quite Low
Versed 8 42.84 Quite Low
Inflammation 68 41.92 Quite Low
anesthesia 4 38.52 Quite Low
metalloproteinase 24 20.00 Low Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 20 99.62 Very High Very High Very High
Necrosis 28 97.16 Very High Very High Very High
Injury 264 94.84 High High
Hyperplasia 8 85.60 High High
Pressure And Volume Under Development 14 84.44 Quite High
Solid Tumor 2 70.32 Quite High
Myeloid Leukemia 170 61.32 Quite High
Cv Unclassified Under Development 36 50.00 Quite Low
Leukemia 30 50.00 Quite Low
Reperfusion Injury 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
Gene_expression (kinases) of TEC
1) Confidence 0.31 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
Gene_expression (kinases) of TEC
2) Confidence 0.31 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0
Important is the chaotic arrangement of TEC that are dedifferentiated (absence of polarization, absence of brush border, high nuclear/cytoplasm ratio) and the presence of numerous mitotic figures, indicating high proliferation and hence reparative processes within the tubules.
Gene_expression (arrangement) of TEC in tubules
3) Confidence 0.29 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 1.10 Pain Relevance 0.03
Macrophages, neutrophils, T cells and apoptotic and proliferating TEC were counted in the corticomedullar region in 10 randomly chosen, non-overlapping high power fields (×40 magnification).


Gene_expression (counted) of TEC in T cells associated with apoptosis
4) Confidence 0.25 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 0.26 Pain Relevance 0.06
Macrophages, neutrophils, T cells and apoptotic and proliferating TEC were counted in the corticomedullar region in 10 randomly chosen, non-overlapping high power fields (×40 magnification).


Gene_expression (counted) of TEC in Macrophages associated with apoptosis
5) Confidence 0.09 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 0.26 Pain Relevance 0.06
Macrophages, neutrophils, T cells and apoptotic and proliferating TEC were counted in the corticomedullar region in 10 randomly chosen, non-overlapping high power fields (×40 magnification).


Gene_expression (counted) of TEC in neutrophils associated with apoptosis
6) Confidence 0.09 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

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