INT313252

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Best1) cellular_component (Best1) biological_process (Best1)
Best1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 69 97.76 Very High Very High Very High
antiepileptic Drug 96 95.48 Very High Very High Very High
Action potential 75 84.24 Quite High
Glutamate 90 74.92 Quite High
antagonist 24 71.92 Quite High
Neuronal excitability 60 50.00 Quite Low
Lamotrigine 48 29.84 Quite Low
gABA 87 5.00 Very Low Very Low Very Low
fluoxetine 18 5.00 Very Low Very Low Very Low
anticonvulsant 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 48 97.00 Very High Very High Very High
Toxicity 3 59.48 Quite High
Syndrome 6 57.64 Quite High
Convulsion 15 56.48 Quite High
Partial Seizures 9 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To provide a more complete correlation between these effects and the corresponding VmD estimations of Ebg and Ibg, we tested the effects of felbamate and gabapentin on sIPSCs, and tiagabine on both sIPSCs and sEPSCs.
Gene_expression (estimations) of VmD associated with gabapentin
1) Confidence 0.05 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.29
However, in our VmD experiments, Ibg was slightly, but not significantly reduced in the presence of felbamate (6.7±2.2 versus 5.4±1.4 nS; Fig. 3B).
Gene_expression (experiments) of VmD
2) Confidence 0.05 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.29 Pain Relevance 0.10
Traub et al., 2004; Nemani and Binder, 2005) and these are also not accounted for directly by VmD.
Neg (not) Gene_expression (accounted) of VmD
3) Confidence 0.05 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

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