INT313290

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NFE2L2, NFE2L2, KEAP1) cytoplasm (NFE2L2, NFE2L2, KEAP1) cytosol (NFE2L2, NFE2L2)
plasma membrane (NFE2L2, NFE2L2) DNA binding (NFE2L2, NFE2L2) endoplasmic reticulum (KEAP1)
Anatomy Link Frequency
hinge 3
NFE2L2 (Homo sapiens)
NFE2L2 (Homo sapiens)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 87.76 High High
Targeted Disruption 1 85.24 High High
Toxicity 1 84.68 Quite High
Bone Disease 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The “hinge and latch” model of Nrf2 regulation proposes that two distinct binding sites in Nrf2 facilitate the interaction with a Keap1 dimer (8).
Nrf2 Binding (binding) of in hinge Positive_regulation (facilitate) of Nrf2 Binding (interaction) of Keap1 in hinge
1) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.38 Pain Relevance 0

General Comments

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