INT313293

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (KEAP1, GOPC) Golgi apparatus (GOPC) endoplasmic reticulum (KEAP1)
nucleolus (KEAP1) plasma membrane (GOPC) nucleus (KEAP1)
Anatomy Link Frequency
HeLa 1
KEAP1 (Homo sapiens)
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 12.56 Low Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 65.84 Quite High
Hepatocellular Cancer 4 62.48 Quite High
Stress 14 5.00 Very Low Very Low Very Low
Bone Disease 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Spontaneous Fractures 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UBA SQSTM1-FLAG/His mutant lacking the ubiquitin-associated domain was also capable of binding endogenous Keap1 in HEK293T and HeLa cells (Fig. 1B), demonstrating that the interaction between Keap1 and SQSTM1 was not dependent on the presence of the ubiquitin-associated domain of SQSTM1 and implying that the ubiquitination of Keap1 is not required for its association with SQSTM1.
Keap1 Binding (binding) of Fig in HeLa
1) Confidence 0.04 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
Endogenous Keap1 was identified as a co-precipitating protein (Fig. 1C), demonstrating that SQSTM1 is a binding partner of Keap1 under physiological conditions.


Keap1 Binding (partner) of Fig
2) Confidence 0.04 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.24 Pain Relevance 0

General Comments

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