INT313296

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PGAM5) endoplasmic reticulum (KEAP1) nucleolus (KEAP1)
nucleus (KEAP1) cytoplasm (KEAP1)
KEAP1 (Homo sapiens)
PGAM5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 87.68 High High
Repression 1 8.48 Low Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, Keap1 associates with PGAM5, which reportedly tethers Keap1 and Nrf2 to the outer membrane of the mitochondria (16, 17), implying that the Keap1·Nrf2 complex may be well placed to sense the disruption of mitochondrial function and subsequent elevated generation of reactive oxygen species that can contribute to the onset of oxidative stress.
Keap1 Binding (associates) of PGAM5 associated with stress
1) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.15 Pain Relevance 0

General Comments

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