INT313299

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NFE2L2, KEAP1) cytoplasm (NFE2L2, KEAP1) cytosol (NFE2L2)
endoplasmic reticulum (KEAP1) nucleolus (KEAP1) plasma membrane (NFE2L2)
NFE2L2 (Homo sapiens)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 87.48 High High
Targeted Disruption 1 49.36 Quite Low
Toxicity 1 48.80 Quite Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modification of cysteine residues within Keap1 is postulated to cause a conformational change in the protein that disrupts the interaction between Keap1 and the low affinity 29DLG31 motif within Nrf2, perturbing the ability of Keap1 to direct the ubiquitination and proteasomal degradation of the transcription factor (8).
Negative_regulation (disrupts) of Nrf2 Binding (interaction) of Keap1
1) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.14 Pain Relevance 0

General Comments

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