INT313303

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SQSTM1, GOPC) cell differentiation (SQSTM1) nucleoplasm (SQSTM1)
Golgi apparatus (GOPC) response to stress (SQSTM1) cytosol (SQSTM1)
Anatomy Link Frequency
HeLa 1
CFPAC-1 1
SQSTM1 (Homo sapiens)
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 2 99.82 Very High Very High Very High
Hepatocellular Cancer 2 98.86 Very High Very High Very High
Stress 7 5.00 Very Low Very Low Very Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In HeLa (cervical adenocarcinoma), HEK293T (kidney), HepG2 (hepatocellular carcinoma), Huh-7 (hepatocellular carcinoma), and CFPAC-1 (pancreatic ductal adenocarcinoma) cells, depletion of SQSTM1 with si-SQSTM1 h3 consistently resulted in a increase in the basal protein level of Keap1 (Fig. 2A).
Negative_regulation (depletion) of SQSTM1 in CFPAC-1 Positive_regulation (increase) of in HeLa Fig associated with adenocarcinoma and hepatocellular cancer
1) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.39 Pain Relevance 0

General Comments

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