INT313317

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (KEAP1) nucleolus (KEAP1) nucleus (KEAP1)
cytoplasm (KEAP1)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 33.00 Quite Low
Hepatocellular Cancer 4 31.08 Quite Low
Stress 14 5.00 Very Low Very Low Very Low
Bone Disease 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Spontaneous Fractures 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, RNA interference (RNAi) depletion of SQSTM1 resulted in an increase in the protein level of Keap1 and a concomitant decrease in the protein level of Nrf2 in the absence of changes in Keap1 or Nrf2 mRNA levels.
Positive_regulation (resulted) of Positive_regulation (increase) of Keap1
1) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
In si-SQSTM1-transfected cells, however, the half-life of Keap1 almost doubled to 21.1 h (Fig. 3D), indicating that siRNA depletion of SQSTM1 causes an increase in the basal protein level of Keap1 by slowing its rate of degradation.
Positive_regulation (causes) of Positive_regulation (increase) of Keap1
2) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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