INT313321

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
Anatomy Link Frequency
Hepa-1c1c7 2
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 40.08 Quite Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Hepa-1c1c7 cells transfected with si-SQSTM1 m3 and m4, the basal mRNA level of three Nrf2-regulated genes, heme oxygenase 1, GCLC, and NAD(P)H:quinone oxidoreductase 1, was reduced significantly, between 37 and 61% compared with si-CON-transfected cells (Fig. 4A).
Negative_regulation (reduced) of Transcription (level) of GCLC in Hepa-1c1c7
1) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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