INT31333

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 8.78
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Esr2) mitochondrion (Esr2) plasma membrane (Esr2)
nucleus (Esr2) enzyme binding (Esr2) DNA binding (Esr2)
Anatomy Link Frequency
bladder 2
skin 2
brain 1
muscle fibers 1
endometrium 1
Esr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 30 100.00 Very High Very High Very High
agonist 12 99.96 Very High Very High Very High
dorsal root ganglion 8 99.84 Very High Very High Very High
cerebral cortex 2 99.68 Very High Very High Very High
Enkephalin 2 99.64 Very High Very High Very High
Hippocampus 2 98.84 Very High Very High Very High
Central nervous system 4 98.48 Very High Very High Very High
pain pelvic 5 98.04 Very High Very High Very High
Pain 18 97.60 Very High Very High Very High
antagonist 12 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.96 Very High Very High Very High
Endometriosis (extended) 17 99.84 Very High Very High Very High
Ganglion Cysts 9 99.84 Very High Very High Very High
Breast Cancer 6 99.54 Very High Very High Very High
Neurodegenerative Disease 3 98.52 Very High Very High Very High
Reprotox - General 3 9 98.04 Very High Very High Very High
Pain 12 97.60 Very High Very High Very High
Neuropathic Pain 6 97.52 Very High Very High Very High
INFLAMMATION 21 97.24 Very High Very High Very High
Polyps 3 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells.
Gene_expression (expressed) of ERbeta in immune cells
1) Confidence 0.69 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18691380 Disease Relevance 1.00 Pain Relevance 0.64
Estrogen acting through two estrogen receptors (ERs), ERalpha and ERbeta, regulates multiple functions in the central nervous system.
Gene_expression (acting) of ERbeta in central nervous system associated with central nervous system
2) Confidence 0.67 Published 2010 Journal Prog. Brain Res. Section Abstract Doc Link 20478441 Disease Relevance 0.05 Pain Relevance 0.16
ERbeta influences on non-reproductive processes and appears to be the main ER subtype expressed in the cerebral cortex, the hippocampus, the cerebellum and the dorsal raphe.
Gene_expression (expressed) of ERbeta in cerebral cortex associated with hippocampus, raphe and cerebral cortex
3) Confidence 0.60 Published 2010 Journal Prog. Brain Res. Section Abstract Doc Link 20478441 Disease Relevance 0.08 Pain Relevance 0.25
The compound appeared to be equally effective in gonad-intact as in ovariectomized mice, and analysed recovered lesions expressed ERalpha but not ERbeta mRNA.
Neg (not) Spec (analysed) Gene_expression (expressed) of ERbeta in gonad
4) Confidence 0.59 Published 2005 Journal Hum. Reprod. Section Body Doc Link 15618247 Disease Relevance 0.22 Pain Relevance 0
To determine which estrogen receptor mediates rapid actions of estrogen, we showed ERalpha and ERbeta expression in DRG neurons from wild-type (WT) female mice by RT-PCR.
Gene_expression (expression) of ERbeta in neurons associated with dorsal root ganglion
5) Confidence 0.54 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15952176 Disease Relevance 0.78 Pain Relevance 0.42
Estrogen receptors (ERs) alpha and beta are ligand-dependent transcription factors that are expressed in skin, and an ERbeta agonist has previously shown efficacy in vivo in models of pain and inflammation.
Gene_expression (expressed) of ERbeta in skin associated with pain, inflammation and agonist
6) Confidence 0.53 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20110405 Disease Relevance 0.51 Pain Relevance 0.46
These activities of ERbeta ligands in skin cells correlated with the expression levels of ERbeta and showed reversal by treatment with a potent synthetic ER antagonist.
Gene_expression (expression) of ERbeta in skin associated with antagonist
7) Confidence 0.53 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20110405 Disease Relevance 0.85 Pain Relevance 0.47
An ER alpha-selective agonist was equally potent in activating [Ca2+]i transients, and E2 remained effective in ERbeta knockout x GnRH-Pericam mice.
Gene_expression (effective) of ERbeta associated with targeted disruption and agonist
8) Confidence 0.39 Published 2008 Journal Endocrinology Section Abstract Doc Link 18703628 Disease Relevance 0.17 Pain Relevance 0.39
Using immunohistochemistry, we demonstrated that the mucosa is the primary source of NGF in the mouse bladder, and the bladder mucosa also expresses estrogen receptor (ER)-alpha, ER-beta, and the high-affinity NGF receptor tyrosine kinase A.
Gene_expression (source) of ER-beta in bladder associated with nerve growth factor
9) Confidence 0.38 Published 2001 Journal Urology Section Abstract Doc Link 11378049 Disease Relevance 0.61 Pain Relevance 0.96
The estrogen receptors ERalpha and ERbeta are present in the brain and their targeting could bring selectivity and reduced risk of cancer.
Gene_expression (present) of ERbeta in brain associated with cancer
10) Confidence 0.33 Published 2008 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17936613 Disease Relevance 0.25 Pain Relevance 0.29
Using immunohistochemistry, we demonstrated that the mucosa is the primary source of NGF in the mouse bladder, and the bladder mucosa also expresses estrogen receptor (ER)-alpha, ER-beta, and the high-affinity NGF receptor tyrosine kinase A.
Gene_expression (expresses) of ER-beta in bladder associated with nerve growth factor
11) Confidence 0.29 Published 2001 Journal Urology Section Abstract Doc Link 11378049 Disease Relevance 0.59 Pain Relevance 0.94
Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells.
Gene_expression (expressed) of ERbeta in neuronal
12) Confidence 0.23 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18691380 Disease Relevance 1.00 Pain Relevance 0.64
Immunohistochemistry demonstrated the presence of NGF, estrogen receptor-alpha, estrogen receptor-beta, and progesterone receptors in these organs.
Gene_expression (presence) of estrogen receptor-beta associated with nerve growth factor
13) Confidence 0.21 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.08 Pain Relevance 0.47
Prediction of endocrine response in breast cancer by immunocytochemical detection of oestrogen receptor in fine-needle aspirates.
Gene_expression (detection) of oestrogen receptor associated with breast cancer
14) Confidence 0.09 Published 1987 Journal Lancet Section Title Doc Link 2888939 Disease Relevance 0.27 Pain Relevance 0.08
An immunocytochemical technique has been developed to detect the oestrogen receptor (ER) in samples obtained by fine-needle aspiration of primary or secondary breast carcinoma tissue. 45 (75%) of 60 samples contained sufficient cells for analysis. 19 (90%) of 21 patients who responded to endocrine therapy had samples with ER-positive cells compared with only 7 (39%) of 18 of those who did not respond (p less than 0.001).
Gene_expression (detect) of oestrogen receptor associated with breast cancer
15) Confidence 0.07 Published 1987 Journal Lancet Section Abstract Doc Link 2888939 Disease Relevance 0.24 Pain Relevance 0.07
Colocalization of oestrogen receptor immunoreactivity and preproenkephalin mRNA expression to neurons in the superficial laminae of the spinal and medullary dorsal horn of rats.
Gene_expression (expression) of oestrogen receptor in spinal associated with dorsal horn and enkephalin
16) Confidence 0.05 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8950107 Disease Relevance 0 Pain Relevance 0.31
It is not known if estrogen receptor beta is expressed, but levator ani muscle fibers show nuclear expression of progesterone and androgen receptors [26].
Gene_expression (expressed) of estrogen receptor beta in muscle fibers
17) Confidence 0.04 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.17 Pain Relevance 0
A comparison of oestrogen receptor and progesterone receptor expression in endometrial polyps and endometrium of premenopausal women.
Gene_expression (expression) of oestrogen receptor in endometrium associated with endometriosis (extended)
18) Confidence 0.02 Published 2009 Journal J Obstet Gynaecol Section Title Doc Link 19835506 Disease Relevance 0.65 Pain Relevance 0.09
The objective of this study was to measure the expression of hormone receptors (oestrogen receptor and progesterone receptor) in endometrial polyps and compare the results to surrounding endometrial tissue.
Gene_expression (expression) of oestrogen receptor associated with endometriosis (extended)
19) Confidence 0.02 Published 2009 Journal J Obstet Gynaecol Section Abstract Doc Link 19835506 Disease Relevance 0.65 Pain Relevance 0.10
The study showed that the expression of oestrogen receptor was higher whereas the expression of progesterone receptor was lower than that of adjacent endometrial tissue.
Gene_expression (expression) of oestrogen receptor
20) Confidence 0.02 Published 2009 Journal J Obstet Gynaecol Section Abstract Doc Link 19835506 Disease Relevance 0.61 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox