INT313371

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) structural molecule activity (Gfap) plasma membrane (Cnr1)
extracellular matrix organization (Gfap) cytoplasm (Gfap) response to stress (Cnr1)
Anatomy Link Frequency
Spinal cord 2
Cnr1 (Rattus norvegicus)
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 20 95.00 High High
Endocannabinoid 25 92.48 High High
Pain 8 90.00 High High
Acute pain 2 84.96 Quite High
Inflammation 12 73.64 Quite High
Perioperative pain 21 73.44 Quite High
allodynia 19 63.12 Quite High
withdrawal 13 59.92 Quite High
intrathecal 6 46.16 Quite Low
Neuropathic pain 6 46.08 Quite Low
Disease Link Frequency Relevance Heat
Pain 21 90.00 High High
INFLAMMATION 13 73.64 Quite High
Post Operative Pain 22 73.44 Quite High
Neuropathic Pain 25 63.12 Quite High
Hypersensitivity 17 40.32 Quite Low
Disease 3 24.72 Low Low
Nociception 8 19.60 Low Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal cord sections from the AM281 + AM630/PPF group demonstrated significantly lower GFAP and pospho-p38 staining compared to sections from AM281 + AM630/Saline animals, indicating that propentofylline treatment had reversed the persistent increase in spinal GFAP expression and p38 phosphorylation induced by the dual CB1/CB2 receptor blockade (Figure 8).


CB1 Positive_regulation (induced) of Gene_expression (expression) of GFAP in Spinal cord associated with spinal cord
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.39 Pain Relevance 0.50

General Comments

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