INT31340

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Context Info
Confidence 0.46
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 10.50
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
plasma 4
liver 4
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 28 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
Paracetamol 104 99.98 Very High Very High Very High
ischemia 20 99.68 Very High Very High Very High
addiction 1 93.52 High High
abdominal pain 6 92.96 High High
antagonist 2 91.24 High High
opiate 1 90.44 High High
nud 1 90.00 High High
Bile 11 85.20 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 100.00 Very High Very High Very High
Cv Unclassified Under Development 22 99.68 Very High Very High Very High
Congenital Anomalies 3 99.54 Very High Very High Very High
Coagulation Disorder 1 98.72 Very High Very High Very High
Hepatotoxicity 86 97.96 Very High Very High Very High
Thrombocytopenia 1 97.96 Very High Very High Very High
Disease 16 97.20 Very High Very High Very High
Jaundice 3 96.40 Very High Very High Very High
Pancreatitis 4 95.96 Very High Very High Very High
Dyskinesias 1 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen-induced liver function abnormalities were characterized by elevation of transaminase levels with ALT higher than AST(6/6), coagulopathy(5/6), thrombocytopenia (1/6), but absence of jaundice(6/6).
Positive_regulation (elevation) of Gene_expression (levels) of transaminase in liver associated with coagulation disorder, paracetamol, congenital anomalies, thrombocytopenia and jaundice
1) Confidence 0.46 Published 1997 Journal Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Section Abstract Doc Link 9473817 Disease Relevance 0.96 Pain Relevance 0.47
METHODS: Questionnaires mailed to the medical directors of 76 poison centres in North America and 48 poison centres in Europe asked respondents to comment on the management of a hypothetical case of a child who had received repeated doses of paracetamol at a daily dose of 90 mg/kg during a febrile illness and who presented to the emergency department with mildly elevated serum transaminase levels.
Positive_regulation (elevated) of Gene_expression (levels) of transaminase
2) Confidence 0.38 Published 2002 Journal Drug Saf Section Body Doc Link 12113645 Disease Relevance 0.07 Pain Relevance 0
Animals fed corn oil and/or low protein levels showed significant increases in both GOT and GPT levels (Fig. 1).
Positive_regulation (increases) of Gene_expression (levels) of GOT
3) Confidence 0.30 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.57 Pain Relevance 0.39
Animals fed PUFA and/or low protein diet had significantly elevated plasma GPT and GOT levels and decreased GSH levels after acetaminophen challenge.
Positive_regulation (elevated) of Gene_expression (levels) of GOT in plasma associated with paracetamol
4) Confidence 0.30 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.28 Pain Relevance 0.26
mg/kg ISO subcutaneously) showed significant increase (P < .001) in serum levels of CK-MB, LDH, GOT, ALK-P and uric acid compared to Group I (vehicle-treated rats injected with normal saline 2?
Positive_regulation (increase) of Gene_expression (levels) of GOT
5) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.19 Pain Relevance 0
It has been reported that when the liver is damaged with the introduction of infectious agents or chemicals, a significant increase in the levels of GOT and GPT were seen in the serum [38], and this increase has been attributed to damage to the structural integrity of the liver.
Positive_regulation (increase) of Gene_expression (levels) of GOT in liver
6) Confidence 0.19 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.59 Pain Relevance 0
Oxytocin treatment significantly reversed the I/R-induced elevations in serum transaminase and TNF-alpha levels and in hepatic MPO and collagen levels, and reduced the hepatic damage scores.
Positive_regulation (elevations) of Gene_expression (levels) of serum transaminase associated with urological neuroanatomy
7) Confidence 0.19 Published 2008 Journal Peptides Section Abstract Doc Link 18403049 Disease Relevance 1.21 Pain Relevance 0.24
Oxytocin treatment significantly reversed the I/R-induced elevations in serum transaminase and TNF-alpha levels and in hepatic MPO and collagen levels, and reduced the hepatic damage scores.
Positive_regulation (elevations) of Gene_expression (levels) of serum transaminase associated with urological neuroanatomy
8) Confidence 0.19 Published 2008 Journal Peptides Section Abstract Doc Link 18403049 Disease Relevance 1.21 Pain Relevance 0.24
[Significance of elevated transaminase levels at the end of pregnancy].
Positive_regulation (elevated) of Gene_expression (levels) of transaminase
9) Confidence 0.15 Published 1994 Journal Presse Med Section Title Doc Link 8022721 Disease Relevance 1.09 Pain Relevance 0.22
Pari and Murugavel [47] reported that the increased level of serum enzymes (GPT, GOT, and ALP), bilirubin, lipids and plasma thiobarbituric acid-reactive substances (TBARS), and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with ?
Positive_regulation (increased) of Gene_expression (level) of GOT in plasma
10) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0.24 Pain Relevance 0
Rats administered with ISO showed significant increase in the serum levels of glutamate oxaloacetate transaminase, alkaline phosphotase, creatinine kinase isoenzymes, lactate dehydrogenase, and uric acid, while F1 and F2 treatment showed significant reduction in the same.
Positive_regulation (increase) of Gene_expression (levels) of glutamate oxaloacetate transaminase associated with glutamate
11) Confidence 0.14 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952329 Disease Relevance 0 Pain Relevance 0.05
Dulundu et al. [48] demonstrated that serum GPT, GOT, and lactate dehydrogenase (LDH) activities and cytokine, TNF-alpha and IL-1beta levels were elevated in the ischemia/reperfusion rats group, while this increase was significantly lower in the group of animals treated concomitantly with lipoic acid.
Positive_regulation (elevated) of Gene_expression (levels) of GOT associated with ischemia and cytokine
12) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0.71 Pain Relevance 0.24
Laboratory studies disclosed increases in the serum alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and serum amylase levels.
Positive_regulation (increases) of Gene_expression (levels) of transaminase
13) Confidence 0.13 Published 1998 Journal Hepatogastroenterology Section Abstract Doc Link 9840091 Disease Relevance 0.34 Pain Relevance 0.18
Laboratory studies disclosed increases in the serum alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and serum amylase levels.
Positive_regulation (increases) of Gene_expression (levels) of transaminase
14) Confidence 0.13 Published 1998 Journal Hepatogastroenterology Section Abstract Doc Link 9840091 Disease Relevance 0.34 Pain Relevance 0.18
Six of eight patients with peak AST levels greater than 1,000 IU/L had increased transaminase levels during the 24 hours after acetaminophen ingestion.
Positive_regulation (increased) of Gene_expression (levels) of transaminase
15) Confidence 0.12 Published 1995 Journal Ann Emerg Med Section Body Doc Link 7793720 Disease Relevance 0 Pain Relevance 0
The incidence of untoward effects was low in both treatment groups, and abnormal results in laboratory tests were observed in only one patient, a chronic alcoholic receiving famotidine, who withdrew from the study because of a slight elevation in serum transaminase levels.
Positive_regulation (elevation) of Gene_expression (levels) of transaminase
16) Confidence 0.10 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2889255 Disease Relevance 0.67 Pain Relevance 0.16
Naltrexone may act as a potential hepatotoxin, as reflected in the elevation of transaminase levels.
Positive_regulation (elevation) of Gene_expression (levels) of transaminase
17) Confidence 0.10 Published 1994 Journal J Clin Pharmacol Section Abstract Doc Link 7983232 Disease Relevance 0.54 Pain Relevance 0.18
Leukocytosis and mild hyperbilirubinemia were detected in 5, elevated serum transaminase levels in 4, hyperglycemia in 1 and constipation in 1 patient(s).
Positive_regulation (elevated) of Gene_expression (levels) of transaminase
18) Confidence 0.06 Published 2008 Journal Ulus Travma Acil Cerrahi Derg Section Body Doc Link 18781417 Disease Relevance 0.08 Pain Relevance 0
Administration of paracetamol resulted in elevated levels of GPT, GOT, AKKP and TB by three to four folds indicating development of hepatotoxicity.
Positive_regulation (resulted) of Gene_expression (levels) of GOT associated with paracetamol and hepatotoxicity
19) Confidence 0.05 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 0.28 Pain Relevance 0.16
Administration of paracetamol resulted in elevated levels of GPT, GOT, AKKP and TB by three to four folds indicating development of hepatotoxicity.
Positive_regulation (elevated) of Gene_expression (levels) of GOT associated with paracetamol and hepatotoxicity
20) Confidence 0.05 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 0.28 Pain Relevance 0.16

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