INT313408

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.74
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 60 81.20 Quite High
Catecholamine 18 50.32 Quite High
Substantia nigra 27 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 95.60 Very High Very High Very High
Parkinson's Disease 54 86.04 High High
Aging 9 77.20 Quite High
Disease 3 45.60 Quite Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings raised the possibility that phosphorylation of other TH serines might be similarly affected by a-Syn overexpression.
Spec (might) Regulation (affected) of Phosphorylation (phosphorylation) of TH
1) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.48 Pain Relevance 0.03
To evaluate if in vivo overexpression of a-Syn altered TH phosphorylation, we compared striatal immunoblots from homozygous WT a-Syn-overexpressing TH-promoter mice (WT-Syn++) to non-transgenic control mice (Non-Tg) in the same genetic background in which total a-Syn overexpression is ?
Regulation (altered) of Phosphorylation (phosphorylation) of TH associated with targeted disruption
2) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.26 Pain Relevance 0.04
To determine whether reduced TH phosphorylation reflected changes in TH enzymatic activity in striatum, we evaluated 15 mice per condition using a well characterized TH activity assay with minor modifications.
Spec (whether) Regulation (changes) of Spec (whether) Phosphorylation (phosphorylation) of TH in striatum
3) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox