INT313420

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 60 99.56 Very High Very High Very High
Substantia nigra 27 5.00 Very Low Very Low Very Low
Catecholamine 18 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 9 85.44 High High
Targeted Disruption 30 74.88 Quite High
Parkinson's Disease 54 50.56 Quite High
Apoptosis 9 46.64 Quite Low
Toxicity 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that TH activation requires TH-Ser-40 phosphorylation; thus, we also measured Ser(P)-40 levels in mouse striatum.
Positive_regulation (requires) of Positive_regulation (activation) of TH in striatum
1) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.22 Pain Relevance 0.03
This possibility is also supported by findings by others in which RNAi-mediated silencing of endogenous a-Syn led to increased levels of TH phosphorylation, TH activity, and dopamine in MN9D cells (8).
Positive_regulation (led) of Positive_regulation (increased) of TH associated with dopamine
2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.05
Although that study did not measure the effect of native a-Syn phosphorylation, their work clearly supports our findings that TH inhibition is attenuated by a-Syn Ser-129 phosphorylation (Fig. 7C), which likely led to the measurable increase in TH-Ser(P)-40 and dopamine noted in their S129D cells.
Positive_regulation (led) of Positive_regulation (increase) of TH-Ser associated with dopamine
3) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.14 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox