INT313423

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 40 80.96 Quite High
Potency 2 62.16 Quite High
midbrain 8 35.16 Quite Low
Substantia nigra 18 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 64.04 Quite High
Parkinson's Disease 36 56.48 Quite High
Apoptosis 6 25.24 Quite Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In experiments utilizing a phosphopeptide substrate (pT), PP2A efficiently cleaved phosphate from pT (362 ± 108 pmol/min/?
Positive_regulation (experiments) of Localization (cleaved) of PP2A
1) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
These findings are supported by our in vivo studies (Figs. 3 and 6), suggesting the possibility that (i) TH inhibition may be caused by an up-regulation of PP2A activity that is triggered by a-Syn overexpression, (ii) PP2A activation and TH inhibition may be independently triggered by a-Syn overexpression leading to interactions that affect both enzymes, or (iii) that TH inhibition may be an additive consequence of a-Syn overexpression and its ability to activate PP2A.
Positive_regulation (activate) of Localization (activation) of PP2A
2) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.12 Pain Relevance 0.07

General Comments

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