INT313428

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) transport (Syp)
oxidoreductase activity (Th) nucleus (Th) protein complex (Syp)
Syp (Mus musculus)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 40 33.92 Quite Low
Substantia nigra 18 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 36 82.84 Quite High
Apoptosis 6 78.92 Quite High
Aging 6 67.52 Quite High
Stress 4 17.56 Low Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, it remains to be determined the exact mechanism(s) whereby a-Syn mediates TH inhibition and whether it occurs by a direct interaction between a-Syn and TH or indirectly by a-Syn-mediated PP2A activation.
Syn Binding (interaction) of TH
1) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.31 Pain Relevance 0
We noted similar effects of transiently overexpressed a-Syn on TH-Ser(P)-19 in MN9D cells as well as in PC12 cells in which a-Syn overexpression is inducible (not shown), confirming an association between a-Syn and TH that reduces TH-Ser(P)-19 levels.
Syn Binding (association) of TH
2) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0

General Comments

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