INT313430

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syp) protein complex (Syp) cytoplasm (Ppp2ca)
cytosol (Ppp2ca) chromosome (Ppp2ca) nucleus (Ppp2ca)
Syp (Mus musculus)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 80 94.16 High High
Potency 4 76.24 Quite High
Substantia nigra 36 45.76 Quite Low
midbrain 16 25.68 Quite Low
Catecholamine 24 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 12 77.24 Quite High
Parkinson's Disease 72 42.36 Quite Low
Apoptosis 12 38.44 Quite Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our work using in vitro models has demonstrated that PP2A dephosphorylates TH-Ser(P)-19 (Fig. 2), that a-Syn activates PP2A and inhibits TH, and further, that a-Syn Ser(P)-129 attenuates both effects (Figs. 5 and 7).
Syn Positive_regulation (activates) of PP2A
1) Confidence 0.66 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.08 Pain Relevance 0.05
Our earlier work using stably transfected MN9D cells and inducible PC12 cells demonstrated that overexpression of WT a-Syn activates PP2A (43); however, it is not known if A53T mutant a-Syn might have a similar effect on PP2A activity or, if so, whether it also occurs in vivo.
Syn Positive_regulation (activates) of PP2A
2) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
g of protein), and both phosphorylated and unphosphorylated a-Syn enhanced PP2A activity; however, unphosphorylated a-Syn activated PP2A more (1421 ± 73 pmol/min/?
Syn Positive_regulation (activated) of PP2A
3) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.04
Together the data strongly suggest that Ser-129 phosphorylation modulates a-Syn ability to stimulate PP2A activity in MN9D cells.
Syn Positive_regulation (stimulate) of PP2A
4) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0

General Comments

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