INT313439

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) transport (Syp)
oxidoreductase activity (Th) nucleus (Th) protein complex (Syp)
Anatomy Link Frequency
dopaminergic neurons 1
Syp (Mus musculus)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 18 77.20 Quite High
Dopamine 60 73.68 Quite High
Substantia nigra 27 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 85.96 High High
Parkinson's Disease 54 51.00 Quite High
Apoptosis 9 5.00 Very Low Very Low Very Low
Aging 9 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the above findings, we surmised that if a-Syn inhibits TH and stimulates PP2A in dopaminergic neurons in vivo, then the absence of a-Syn in ASKO mice would produce effects opposite those of a-Syn overexpression.
Syn Negative_regulation (inhibits) of TH in dopaminergic neurons
1) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.04
Phosphorylation of a-Syn Ser-129 by Polo-like-kinase 2 in vitro reduced the ability of a-Syn to inhibit TH or activate PP2A, identifying a novel regulatory role for Ser-129 on a-Syn.
Syn Negative_regulation (inhibit) of TH
2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.14 Pain Relevance 0.09
We noted similar effects of transiently overexpressed a-Syn on TH-Ser(P)-19 in MN9D cells as well as in PC12 cells in which a-Syn overexpression is inducible (not shown), confirming an association between a-Syn and TH that reduces TH-Ser(P)-19 levels.
Syn Negative_regulation (reduces) of TH-Ser
3) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0

General Comments

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