INT313446

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.62
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syp) protein complex (Syp) cytoplasm (Ppp2ca)
cytosol (Ppp2ca) chromosome (Ppp2ca) nucleus (Ppp2ca)
Anatomy Link Frequency
brain 1
Syp (Mus musculus)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 100 87.20 High High
Neurotransmitter 5 74.00 Quite High
Catecholamine 30 65.04 Quite High
Substantia nigra 45 5.00 Very Low Very Low Very Low
midbrain 20 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
lidocaine 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 15 94.76 High High
Parkinson's Disease 90 91.92 High High
Apoptosis 15 88.00 High High
Targeted Disruption 50 33.24 Quite Low
Stress 10 26.64 Quite Low
Toxicity 10 26.32 Quite Low
Neurodegenerative Disease 5 18.72 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide the first evidence that both WT a-Syn and A53T mutant a-Syn regulate TH and PP2A similarly in vitro and in vivo.
Syn Regulation (regulate) of PP2A
1) Confidence 0.58 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
These data provide the first evidence that both WT a-Syn and A53T mutant a-Syn regulate TH and PP2A similarly in vitro and in vivo.
Syn Regulation (regulate) of PP2A
2) Confidence 0.58 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
Although the exact mechanism underlying PP2A regulation by a-Syn is not yet defined, it likely involves a-Syn binding to the PP2A catalytic subunit based on our prior co-immunoprecipitation data (43) and our current findings using recombinant proteins, which require preincubation to affect PP2A activity (Fig. 7).
Syn Regulation (regulation) of PP2A
3) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.17
Because a-Syn Ser-129 phosphorylation reduced the a-Syn effect on TH and PP2A, a shift in a-Syn levels along with changes in the levels of Ser(P)-129 could dysregulate a-Syn-modulated proteins, especially in aging brain (62).
Syn Regulation (effect) of PP2A in brain associated with aging
4) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.30 Pain Relevance 0.03
Collectively our findings provide compelling support for physiological regulation of PP2A and TH by a-Syn, with a-Syn Ser-129 phosphorylation attenuating the effects.
Syn Regulation (regulation) of PP2A
5) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.32 Pain Relevance 0

General Comments

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