INT313456

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ppp2ca, Gopc) cytoplasm (Ppp2ca, Gopc) cytosol (Ppp2ca)
transport (Gopc) Golgi apparatus (Gopc) chromosome (Ppp2ca)
Ppp2ca (Mus musculus)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 40 21.96 Low Low
Substantia nigra 18 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 36 97.24 Very High Very High Very High
Apoptosis 6 94.96 High High
Stress 4 45.40 Quite Low
Aging 6 40.56 Quite Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, Ser(P)-129 is not dephosphorylated by PP2A (72), a finding that we have also reconfirmed (Fig. 7B).
PP2A Spec (finding) Binding (finding) of Fig
1) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.34 Pain Relevance 0
Another major difference between our studies and the AAV rats is the timing of S129A overexpression, implying that perhaps long term S129A overexpression induces excessive and, hence, detrimental PP2A hyperactivation as we observed a potentiation of PP2A activity by S129A both in cells (Fig. 5) and in mice (Fig. 6).
PP2A Binding (activity) of Fig
2) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.34 Pain Relevance 0

General Comments

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