INT313459

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) transport (Syp)
oxidoreductase activity (Th) nucleus (Th) protein complex (Syp)
Syp (Mus musculus)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 18 62.96 Quite High
Catecholamine 12 55.04 Quite High
Dopamine 40 34.48 Quite Low
midbrain 8 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 36 90.76 High High
Targeted Disruption 20 64.72 Quite High
Disease 2 35.52 Quite Low
Aging 6 17.96 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because we previously established that a-Syn overexpression reduces TH-Ser(P)-40 in MN9D cells (43) and reconfirmed this same effect here for wild type a-Syn-overexpressing mice, the data for the remainder of the manuscript will focus entirely on our novel findings related to TH-Ser(P)-19.


Gene_expression (overexpression) of Syn Negative_regulation (reduces) of TH-Ser
1) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.06
PP2A (EC 3.1.3.16) is the main phosphatase for TH dephosphorylation (24, 40–42). a-Syn binds to and stimulates PP2A activity, and furthermore, a-Syn overexpression in dopaminergic cells reduces TH-Ser(P)-40 levels (43).
Gene_expression (overexpression) of Syn Negative_regulation (reduces) of TH-Ser
2) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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