INT313494

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 50 99.20 Very High Very High Very High
Kinase C 4 88.08 High High
Calcium channel 2 77.52 Quite High
member 8 2 75.92 Quite High
Somatostatin 6 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell surface expression of the P2X1 receptor was also unaffected by cholesterol disruption (Fig. 3a, lower panel) demonstrating that a change in receptor number does not account for the inhibition of P2X1 receptor responses.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of P2X1 receptor
1) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.09
For dynasore the increase in immobile fraction following receptor stimulation suggests that agonist induced trafficking plays an important role in the cell surface expression of P2X1 receptors.
Regulation (role) of Gene_expression (expression) of P2X1 associated with agonist
2) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.20
Overall these studies highlight that trafficking plays an important role in the control of the functional expression of P2X1 receptors and their regulation.



Regulation (control) of Gene_expression (expression) of P2X1
3) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.11
Cholesterol depletion did not change the ATP sensitivity or cell surface expression of P2X1 receptors.
Neg (not) Regulation (change) of Gene_expression (expression) of P2X1
4) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04

General Comments

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