INT313554

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
ALOX5 (Homo sapiens)
Cor (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 52 99.24 Very High Very High Very High
Angina 4 53.52 Quite High
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.24 Very High Very High Very High
Calcification 48 97.36 Very High Very High Very High
Atherosclerosis 172 94.80 High High
Diabetes Mellitus 108 91.40 High High
Cardiovascular Disease 44 80.28 Quite High
Stroke 8 53.84 Quite High
Cv General 3 Under Development 4 53.52 Quite High
Myocardial Infarction 16 53.20 Quite High
Nicotine Addiction 12 38.44 Quite Low
Disorder Of Lipid Metabolism 12 29.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNPs in ALOX5 are associated with variation in CorCP, AorCP, and IMT.
ALOX5 Binding (associated) of CorCP
1) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.97 Pain Relevance 0.03
Nonetheless, these data suggest that lipoxygenase pathway variants that are associated with CorCP affect markers of inflammation (CRP, ICAM-1) as well as arterial calcification (MGP).
lipoxygenase Binding (associated) of CorCP associated with calcification and inflammation
2) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.55 Pain Relevance 0.05
The ALOX5 SNP (rs2115819) was associated with both CorCP and AorCP.
ALOX5 Binding (associated) of CorCP
3) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.54 Pain Relevance 0.03
None of the 17 tagging SNPs in the lipoxygenase pathway genes were significantly (P < .05) associated with CorCP (Table 3).
lipoxygenase Binding (associated) of CorCP
4) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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