INT313617

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.53
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
neuronal 1
Bladder 1
hippocampus 1
Pdgfb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 41 99.82 Very High Very High Very High
cytokine 6 98.16 Very High Very High Very High
Dopamine 106 79.04 Quite High
depression 4 51.16 Quite High
nMDA receptor 1 32.36 Quite Low
Glutamate 4 26.68 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 129 100.00 Very High Very High Very High
Convulsion 8 93.60 High High
Mental Disorders 8 77.84 Quite High
Status Epilepticus 2 62.76 Quite High
Depression 4 51.16 Quite High
Injury 33 43.60 Quite Low
Post-traumatic Stress Disorder 18 41.84 Quite Low
Gliosis 1 33.68 Quite Low
Anxiety Disorder 48 5.00 Very Low Very Low Very Low
Fibrosis 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous study had found early and prolonged increases in neuronal Pdgf-a and Pdgf-b mRNA levels on the side ipsilateral to a unilateral 6-OHDA injection in the rat median forebrain bundle [88].
Positive_regulation (increases) of Pdgf-b in neuronal
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.22
The levels of total BDNF mRNA, exons I and IV in the hippocampus of rats subjected to SIS for 2 h were significantly lower than those of rats subjected to sham treatment (Figure 2).
Positive_regulation (subjected) of SIS in hippocampus associated with stress and hippocampus
2) Confidence 0.15 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.95 Pain Relevance 0.12
Another interesting result derived from this study, is that the marked decreases in H3 acetylation at the promoter of exons I, IV, and VI of the BDNF gene in response to SIS spontaneously recovered 24 h after stress.
Positive_regulation (response) of SIS associated with stress
3) Confidence 0.15 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.58 Pain Relevance 0.07
Bladder reconstitution was improved and noted earlier in SIS bladder augments in a rat model [38].
Positive_regulation (augments) of SIS in Bladder
4) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3022195 Disease Relevance 0 Pain Relevance 0
SIS is mainly composed of collagen (90% of dry weight) and contains cytokines and growth factors such as FGF and TGF-?
Positive_regulation (composed) of SIS associated with cytokine
5) Confidence 0.02 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0 Pain Relevance 0.05

General Comments

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