INT313688

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.20
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IFIH1) nucleus (IFIH1) intracellular (IFIH1)
helicase activity (IFIH1) DNA binding (IFIH1) cytoplasm (IFIH1)
IFIH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 64 99.84 Very High Very High Very High
rheumatoid arthritis 3 98.44 Very High Very High Very High
Inflammatory response 1 66.20 Quite High
chemokine 1 57.20 Quite High
Inflammation 13 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pain management 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 145 99.92 Very High Very High Very High
Osteoarthritis 71 99.84 Very High Very High Very High
Lymphedema 84 99.36 Very High Very High Very High
Lymphatic Filariasis 228 98.70 Very High Very High Very High
Rheumatoid Arthritis 3 98.44 Very High Very High Very High
Infection 47 97.96 Very High Very High Very High
Anaemia 2 95.84 Very High Very High Very High
Renal Disease 4 95.48 Very High Very High Very High
Scabies 2 91.84 High High
Onchocerciasis 12 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With such a varying degree of potential economic impact that is also likely dependent on parasite and MDA regimen type, a better understanding of the true relationship between antifilarial drug treatment and filarial morbidity is needed.
Spec (likely) Regulation (dependent) of MDA
1) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.61 Pain Relevance 0
Considering the disease burden of these three infections and their geographic overlap with LF, it is certain that an important reduction in these diseases is found in MDA treatment areas, resulting in health and economic benefits from prevention and diminution of stunting, anaemia, renal disease, and other complications [89], [90].


Regulation (found) of MDA associated with anaemia, lymphatic filariasis, renal disease, disease and infection
2) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.97 Pain Relevance 0
One unique and important finding from the 2008 evaluation is that community-based lymphedema management programs positively affect MDA compliance independently of such programs' effects on the other predictors of compliance.
Regulation (affect) of MDA associated with lymphedema
3) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 0.48 Pain Relevance 0
Of the 60 shear-down-regulated genes, only 3 have been reported to be similarly regulated in OA.
Regulation (regulated) of shear-down-regulated associated with osteoarthritis
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.15 Pain Relevance 0.48

General Comments

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