INT313785

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 18.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
epidermis 9
epithelium 1
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 17 49.40 Quite Low
corticosteroid 17 46.68 Quite Low
imagery 17 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 249 100.00 Very High Very High Very High
Skin Infection 85 99.44 Very High Very High Very High
Bullous Skin Disease 1098 99.36 Very High Very High Very High
Targeted Disruption 737 99.26 Very High Very High Very High
Blister 620 99.12 Very High Very High Very High
Streptococcus Infection 17 98.06 Very High Very High Very High
Skin Diseases 21 97.84 Very High Very High Very High
Disease 170 97.72 Very High Very High Very High
Acantholysis 50 94.64 High High
Monilethrix 17 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we assessed the expression and localization of Dsg1 (?
Gene_expression (expression) of Dsg1
1) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.81 Pain Relevance 0
Upon further analysis, we observed that the site of blister formation in WT mice after ETA treatment was superficial and occurred in the middle of the granular cell layer (Figure 2(b), lower left panel), where Dsg1 is highly expressed.
Gene_expression (expressed) of Dsg1 associated with blister
2) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.02 Pain Relevance 0
These results suggest that coexpression of Dsg2 with Dsg1 in the superficial epidermis may protect from the loss of Dsg1 by ETA although we cannot rule out the possibility that ectopic expression of Dsg2 may also impair the ETA-digestion of Dsg1 molecules.
Gene_expression (coexpression) of Dsg1 in epidermis
3) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.06 Pain Relevance 0
In pemphigus foliaceus (PF), patients develop pathogenic autoantibodies that target Dsg1 and promote cell-cell disadhesion in the superficial epidermis, where Dsg1 is highly expressed, but which lacks Dsg3 and Dsg2.
Gene_expression (expressed) of Dsg1 in epidermis associated with bullous skin disease
4) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.70 Pain Relevance 0
It is well established that ETA cleaves Dsg1 and causes epidermal blisters in the upper layers of the epidermis, where Dsg1 is highly expressed [16].
Gene_expression (expressed) of Dsg1 in epidermis associated with blister
5) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.23 Pain Relevance 0
To detect normal human Ig, the Flag tag, or Dsg1, OCT frozen sections were fixed in methanol (?
Gene_expression (normal) of Dsg1
6) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.22 Pain Relevance 0
To detect normal human Ig, the Flag tag, or Dsg1, OCT frozen sections were fixed in methanol (?
Gene_expression (detect) of Dsg1
7) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.22 Pain Relevance 0
It is well established that ETA cleaves Dsg1 and causes epidermal blisters in the upper layers of the epidermis, where Dsg1 is highly expressed [16].
Gene_expression (cleaves) of Dsg1 in epidermis associated with blister
8) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.21 Pain Relevance 0
These results suggest that coexpression of Dsg2 with Dsg1 in the superficial epidermis may protect from the loss of Dsg1 by ETA although we cannot rule out the possibility that ectopic expression of Dsg2 may also impair the ETA-digestion of Dsg1 molecules.
Gene_expression (expression) of Dsg1 in epidermis
9) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.06 Pain Relevance 0
In pemphigus foliaceus (PF), patients develop pathogenic autoantibodies that target Dsg1 and promote cell-cell disadhesion in the superficial epidermis, where Dsg1 is highly expressed, but which lacks Dsg3 and Dsg2.
Gene_expression (target) of Dsg1 in epidermis associated with bullous skin disease
10) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.60 Pain Relevance 0
Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.
Gene_expression (level) of Dsg1 associated with targeted disruption and bullous skin disease
11) Confidence 0.67 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.63 Pain Relevance 0
Unlike Dsg1 and Dsg3, whose expression is restricted to complex stratified epithelia, Dsg2 and Dsg4 are expressed in a wide range of other cell types.
Gene_expression (expressed) of Dsg1
12) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.22 Pain Relevance 0
Western blotting showed that (1) up-regulation of Dsg2 did not alter the expression level of Dsg1 in newborn mouse skin, and (2) incubation with PF Ig reduced the level of Dsg1 (Figure 4(d)).
Gene_expression (expression) of Dsg1 in skin associated with bullous skin disease
13) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.79 Pain Relevance 0
Conversely, Dsg1 and Dsg4 expression is driven by cell differentiation.
Gene_expression (expression) of Dsg1
14) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.46 Pain Relevance 0
Dsg1 is expressed from the immediate suprabasal layer up, with marked higher abundance in the differentiated granular cell layers.
Gene_expression (expressed) of Dsg1
15) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.47 Pain Relevance 0
Interestingly, in the toxin-mediated disease bullous impetigo (and its generalized form staphylococcal scalded skin syndrome (SSSS)), the bacterium S. aureus produces exfoliative toxins (glutamic-specific serine proteases) that cleave Dsg1 between extracellular domains 3 and 4 [7].
Gene_expression (produces) of Dsg1 in skin associated with streptococcus infection, skin infection and disease
16) Confidence 0.59 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.96 Pain Relevance 0
In the skin of mice, DSG3 is restricted to the basal and immediate suprabasal cell layers, whereas DSG1 and 2 are present throughout the epithelium.
Gene_expression (present) of DSG1 in epithelium
17) Confidence 0.40 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.42 Pain Relevance 0
In mucous membranes, DSG1 and 2 are present throughout the epithelium but are weaker in the deep epidermis where DSG3 dominates as judged by immunohistochemical staining (Figure 1(b)), thus explaining the PV-like acantholysis observed in Dsg3 null oral mucosa.

3.

Gene_expression (present) of DSG1 in epidermis associated with acantholysis and bullous skin disease
18) Confidence 0.35 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.48 Pain Relevance 0
This disorder is generally characterized by the production of pathogenic antibodies targeting different components of cell-cell adhesion, in particular, Dsg1 and Dsg3.
Gene_expression (production) of Dsg1 associated with adhesions
19) Confidence 0.27 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.36 Pain Relevance 0

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