INT313790

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Dsc3) cell adhesion (Dsc3) plasma membrane (Dsc3)
cytoplasm (Dsc3)
Anatomy Link Frequency
epidermis 1
Dsc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acantholysis 40 99.68 Very High Very High Very High
Bullous Skin Disease 195 99.12 Very High Very High Very High
Disease 85 98.16 Very High Very High Very High
Adhesions 70 93.52 High High
Alopecia 55 88.72 High High
Targeted Disruption 15 61.84 Quite High
Autoimmune Disease 25 61.64 Quite High
Injury 10 44.60 Quite Low
Stress 10 41.40 Quite Low
Blister 20 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Dsc3 and Dsg3 Lead to Similar Histopathology but Target Different Tissues
Negative_regulation (Loss) of Dsc3
1) Confidence 0.58 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.60 Pain Relevance 0
Consequently, DSC3 would be the major DSC isoform expressed in the deep layers of the epidermis, thus explaining why loss of Dsc3 causes acantholysis in these cell layers.
Negative_regulation (loss) of Dsc3 in epidermis associated with acantholysis
2) Confidence 0.58 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.16 Pain Relevance 0
This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia.
Negative_regulation (lack) of desmocollin 3
3) Confidence 0.42 Published 2010 Journal Dermatology Research and Practice Section Abstract Doc Link PMC2879910 Disease Relevance 0.46 Pain Relevance 0
Taken together, our mouse study demonstrated that loss of Dsc3 function can lead to PV-like lesions while the human studies cited above suggest that this finding is relevant for at least a subgroup of patients with PV-like disease.
Negative_regulation (loss) of Dsc3 associated with disease and bullous skin disease
4) Confidence 0.42 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.99 Pain Relevance 0
Nevertheless, this report did not provide histological data demonstrating intraepidermal blistering; that is, further evidence is required to convincingly link impaired DSC3 function to intraepidermal blistering in humans.
Negative_regulation (impaired) of DSC3
5) Confidence 0.42 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.94 Pain Relevance 0

General Comments

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