INT31381

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.82
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
annulus 2
mammary glands 1
nerve 1
Gbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 99.92 Very High Very High Very High
Morphine 4 99.56 Very High Very High Very High
noradrenaline 5 99.02 Very High Very High Very High
mu opioid receptor 1 97.80 Very High Very High Very High
Opioid 3 97.64 Very High Very High Very High
opioid receptor 1 96.00 Very High Very High Very High
agonist 5 92.40 High High
antagonist 1 91.72 High High
Clonidine 3 88.20 High High
analgesia 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 2 99.92 Very High Very High Very High
Aging 114 96.12 Very High Very High Very High
Sprains And Strains 47 95.02 Very High Very High Very High
Apoptosis 16 88.12 High High
Necrosis 8 87.60 High High
Bordatella Infection 6 84.36 Quite High
Body Weight 3 66.20 Quite High
Hyperplasia 3 57.36 Quite High
Fibrosis 1 44.40 Quite Low
Retinoblastoma 12 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our analysis showed that mitogen-activated protein kinase p38 (also know as p38, p38 MPA kinase or MPAK14) was significantly upregulated in senescent compared to non-senescent annulus cells.
Positive_regulation (upregulated) of MPA in annulus
1) Confidence 0.45 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.41 Pain Relevance 0
Our analysis showed that mitogen-activated protein kinase p38 (also know as p38, p38 MPA kinase or MPAK14) was significantly upregulated in senescent compared to non-senescent annulus cells.
Positive_regulation (upregulated) of MPA in annulus
2) Confidence 0.45 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.41 Pain Relevance 0
These results suggest that alpha 2-adrenoceptor modulation of noradrenaline release from sympathetic nerve terminals is not dependent on an inhibitory guanine-nucleotide-binding protein.
Neg (not) Positive_regulation (dependent) of guanine-nucleotide-binding protein in nerve associated with noradrenaline
3) Confidence 0.33 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2891042 Disease Relevance 0.42 Pain Relevance 0.28
The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine nucleotide binding protein (G protein)-coupled heptahelical receptor (GPCR), the mu opioid receptor (muOR).
Positive_regulation (mediated) of guanine nucleotide binding protein associated with pain, mu opioid receptor and morphine
4) Confidence 0.23 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.10 Pain Relevance 0.52
When untreated mammary glands from control virgin mice of both strains, without any treatment and in the same phase of the estrous cycle, were compared, BALB/c untreated mammary glands exhibited more ductal side branching than did C57BL/6 glands (Figure 2a,b, left panels), and only BALB/c mice exhibited a significant increase in MPA-induced ductal branching in mammary glands (Figure 2a,b, middle panels; P < 0.001).
Positive_regulation (increase) of MPA in mammary glands associated with sprains and strains
5) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.48 Pain Relevance 0
Recent cloning and expression studies have revealed that the opioid mu-, delta-, kappa- and orphan receptors are seven-transmembrane domain receptors whose actions are mediated through activation of guanine nucleotide binding protein (G-protein).
Positive_regulation (activation) of guanine nucleotide binding protein associated with opioid
6) Confidence 0.07 Published 1998 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 9866825 Disease Relevance 0 Pain Relevance 0.41

General Comments

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