INT31383

Context Info Confidence 0.41 First Reported 1987 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.49 Pain Relevance 0.41

Anatomy Link Frequency nerve 1 finger 1 Gbp1 (Mus musculus)

Pain Link Frequency Relevance Heat noradrenaline 5 98.70 Somatostatin 4 96.92 antagonist 6 91.08 Clonidine 3 87.56 Inflammation 2 75.56 cytokine 2 75.04 Serotonin 11 37.84 agonist 6 37.12 corticosteroid 1 28.48 dexamethasone 1 26.56

Disease Link Frequency Relevance Heat Aging 57 98.14 Bordatella Infection 6 83.72 Sprains And Strains 47 82.28 Shock 4 79.12 INFLAMMATION 2 75.56 Apoptosis 8 73.76 Adhesions 1 72.68 Targeted Disruption 9 62.00 Cancer 24 58.40 Hallucination 2 48.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several genes related to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, inhibitor of growth family member 5 (p28ING5), sphingosine-1-phosphate receptor 2 and somatostatin receptor 3.

Negative_regulation (inhibitor) of MPA in finger associated with aging and somatostatin

1) Confidence 0.41 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.67 Pain Relevance 0.12

These results suggest that alpha 2-adrenoceptor modulation of noradrenaline release from sympathetic nerve terminals is not dependent on an inhibitory guanine-nucleotide-binding protein.

Negative_regulation (inhibitory) of guanine-nucleotide-binding protein in nerve associated with noradrenaline

2) Confidence 0.28 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2891042 Disease Relevance 0.42 Pain Relevance 0.28

were significantly downregulated in both BALB/c MPA-treated and progesterone-treated mice, and it is interesting to note that ER-?

Negative_regulation (downregulated) of MPA-treated

3) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.40 Pain Relevance 0

Consistent with SEA prediction, one such phenotypic hit, MAG-1, was found to be a 1 nM inhibitor of MAO in direct kinetic inhibition studies (58).

Negative_regulation (inhibitor) of MAG-1

4) Confidence 0.02 Published 2010 Journal Biochemistry Section Body Doc Link PMC2994275 Disease Relevance 0 Pain Relevance 0

General Comments

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