INT313838

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 1.21
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fstl3) extracellular region (Fstl3) Golgi apparatus (Fstl3)
nucleus (Fstl3)
Anatomy Link Frequency
skeletal muscle 4
plasma 1
N-18 1
fat 1
muscle 1
Fstl3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 19 60.36 Quite High
Disease Link Frequency Relevance Heat
Body Weight 57 97.22 Very High Very High Very High
Diabetes Mellitus 19 93.52 High High
Metabolic Disorder 57 92.44 High High
Obesity 19 74.60 Quite High
Decapitation 19 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generally higher myostatin precursor and dimer expression was identified in the males compared to females, whereas a consistent dimorphic difference in FSTL-3 expression was not evident; with only a few specific groups within diet showing differences.
Gene_expression (expression) of FSTL-3
1) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
Brief Communication: Sexual dimorphic expression of myostatin and follistatin like-3 in a rat trans-generational under-nutrition model

The detrimental effects of maternal under-nutrition during gestation on fetal development are well known with an increased propensity of metabolic disorders identified in the adult offspring.

Gene_expression (expression) of follistatin like-3 associated with metabolic disorder
2) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Title Doc Link PMC2880107 Disease Relevance 0.15 Pain Relevance 0
Sexual dimorphism was clearly evident in the majority of these measures, including myostatin and FSTL-3 expression.
Gene_expression (expression) of FSTL-3
3) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.14 Pain Relevance 0
The aim of this study was to utilise a model of trans-generational maternal under-nutrition to investigate potential sexual dimorphic changes in the expression of myostatin and FSTL-3 in rat skeletal muscle.


Gene_expression (expression) of FSTL-3 in skeletal muscle
4) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
In this study, irrespective of sex, the expression of FSTL-3, myostatin precursor and dimer were varied in the UNAD HF fed offspring.
Gene_expression (expression) of FSTL-3
5) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0.07 Pain Relevance 0
Overall FSTL-3 expression did not differ between sexes, although difference between sexes within certain treatments and diets were evident.
Gene_expression (expression) of FSTL-3
6) Confidence 0.53 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.07 Pain Relevance 0
The relative optical densities were normalized to sheep muscle expression of myostatin and FSTL-3 protein.


Gene_expression (expression) of FSTL-3 in muscle
7) Confidence 0.47 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
The body weight, body fat, plasma glucose and insulin concentrations of the offspring, both male and female, were investigated in relation to the protein expression of myostatin and its main inhibitor; follistatin like-3 (FSTL-3), in skeletal muscle of mature offspring.
Gene_expression (expression) of FSTL-3 in plasma associated with body weight
8) Confidence 0.47 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.16 Pain Relevance 0
Sexually dimorphic differences were evident in the phenotypic measures investigated and notably, the skeletal muscle expression of myostatin and FSTL-3 proteins.
Gene_expression (expression) of FSTL-3 in skeletal muscle
9) Confidence 0.47 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
Differences in bodyweight and composition, plasma metabolite concentrations and the relative expression of myostatin and FSTL-3 in skeletal muscle were analysed with group, sex and diet included in the model, and all interactions between the main effects were analysed.
Gene_expression (expression) of FSTL-3 in skeletal muscle
10) Confidence 0.47 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
The increased plasma glucose concentrations evident in UNAD offspring could be influenced by the expression of myostatin and FSTL-3 in skeletal muscle, with limited fiber number and size potentially restricting uptake of glucose from the circulation, although further studies are needed to examine this hypothesis.
Gene_expression (expression) of FSTL-3 in skeletal muscle
11) Confidence 0.47 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0.26 Pain Relevance 0
Antibodies from Santa Cruz Biotechnology (CA, USA) were used for the detection of myostatin (1:3000 dilution; Goat Polyclonal GDF-8 (F-13), Sc-34781) and FSTL-3 (1:5000 dilution; Goat Polyclonal FLRG (N-18), Sc-21302) in conjunction with a secondary Polyclonal Rabbit Anti IgG/HRP antibody (1:10000 dilution).
Gene_expression (detection) of FSTL-3 in N-18
12) Confidence 0.46 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0.06 Pain Relevance 0.06
Most notably, UNAD HF females had higher (P < 0.05) FSTL-3 expression than UNAD HF males and in fact, higher (P < 0.01) FSTL-3 expression compared to all other female groups.


Gene_expression (expression) of FSTL-3
13) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
Most notably, UNAD HF females had higher (P < 0.05) FSTL-3 expression than UNAD HF males and in fact, higher (P < 0.01) FSTL-3 expression compared to all other female groups.


Gene_expression (expression) of FSTL-3
14) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
Most notably, UNAD HF females had higher (P < 0.05) FSTL-3 expression than UNAD HF males and in fact, higher (P < 0.01) FSTL-3 expression compared to all other female groups.


Gene_expression (expression) of FSTL-3
15) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
The former group also displayed higher (P < 0.01) FSTL-3 expression compared to all other female groups.
Gene_expression (expression) of FSTL-3
16) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.06 Pain Relevance 0
Most notably, HF fed UNAD females had higher (P < 0.05) FSTL-3 expression than HF fed UNAD males.
Gene_expression (expression) of FSTL-3
17) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.06 Pain Relevance 0
Overall FSTL-3 expression did not differ between sexes, although difference between sexes within certain treatments and diets were evident (Figure 2c).
Gene_expression (expression) of FSTL-3
18) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2880107 Disease Relevance 0 Pain Relevance 0
The body weight, body fat, plasma glucose and insulin concentrations of the offspring, both male and female, were investigated in relation to the protein expression of myostatin and its main inhibitor; follistatin like-3 (FSTL-3), in skeletal muscle of mature offspring.
Gene_expression (expression) of FSTL-3 in fat associated with body weight
19) Confidence 0.16 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2880107 Disease Relevance 0.16 Pain Relevance 0

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