INT313865

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.95
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Pah)
Anatomy Link Frequency
lymphocyte 2
NK cells 2
Pah (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 93.76 High High
cytokine 5 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 66 100.00 Very High Very High Very High
Birth Weight 35 90.40 High High
Nicotine Addiction 30 89.08 High High
Liver Disease 1 88.56 High High
Hypertension 6 83.52 Quite High
Disease Progression 2 80.40 Quite High
Disease 17 76.16 Quite High
Natriuresis 1 73.92 Quite High
Toxicity 7 41.44 Quite Low
Pressure Volume 2 Under Development 2 37.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sildenafil in other acquired PAH
Positive_regulation (acquired) of Gene_expression (acquired) of PAH associated with pulmonary hypertension
1) Confidence 0.47 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.69 Pain Relevance 0.05
For instance, a 100 ng/m3 incremental increase in PAH exposure during month eight was associated with reduction of CD3+ cells by 2.6% (95% CI: 1.2, 3.9) and CD4+ cells by 1.8% (95% CI: 0.6, 2.9).
Positive_regulation (increase) of Gene_expression (exposure) of PAH
2) Confidence 0.21 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0 Pain Relevance 0
For a 100 ng/m3 increase in PAH exposure during month one was associated with a 1.1% (95% CI: 0.3, 2.0) decrease in CD19+ cells (Figure 7).
Positive_regulation (increase) of Gene_expression (exposure) of PAH
3) Confidence 0.21 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0 Pain Relevance 0
For example, there was 1.4% (95% CI: 0.1, 2.7) decrease during month one and 1.2% (95% CI: 0.1, 2.4) increase during month eight for a 100 ng/m3 increase in PAH exposure (Figure 9).
Positive_regulation (increase) of Gene_expression (exposure) of PAH
4) Confidence 0.18 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0 Pain Relevance 0
Results were expressed as changes in distribution of lymphocyte subtype with a monthly average increase of 100 ng/m3 PAH exposure or a monthly average increase of 25 ?
Positive_regulation (increase) of Gene_expression (exposure) of PAH in lymphocyte
5) Confidence 0.18 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0.26 Pain Relevance 0
The percentage of NK cells was lower for those with higher PAH exposures in the first two months, no significant association with exposures from months three through six, and an increase in percentage relative to ambient PAHs measured during months seven through nine.
Positive_regulation (increase) of Gene_expression (exposures) of PAH in NK cells
6) Confidence 0.18 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0 Pain Relevance 0

General Comments

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