INT313867

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6a) plasma membrane (Pde6a)
Anatomy Link Frequency
blood 1
Pde6a (Mus musculus)
Pain Link Frequency Relevance Heat
cva 2 59.96 Quite High
headache 3 56.12 Quite High
carbamazepine 1 28.96 Quite Low
Potency 1 23.04 Low Low
Calcium channel 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nonarteritic Anterior Ischaemic Optic Neuropathy 6 98.24 Very High Very High Very High
Optic Disorders 1 91.60 High High
Syncope 1 81.96 Quite High
Retina Disease 1 59.96 Quite High
Congenital Anomalies 1 58.52 Quite High
Headache 3 56.12 Quite High
Increased Venous Pressure Under Development 5 55.72 Quite High
Diabetes Mellitus 1 53.28 Quite High
Nose Bleeds 2 50.00 Quite Low
Toxicity 2 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While larger doses of sildenafil have been associated with significant reduction in systolic blood pressure approaching 10 mmHg, the FDA-approved dose of 20 mg by mouth 3 times daily has not been shown to significantly affect blood pressure.34 Blurry vision has been described at higher doses, primarily due to minor inhibition of PDE-6 located in the eyes.
Negative_regulation (inhibition) of PDE-6 in blood
1) Confidence 0.14 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 1.08 Pain Relevance 0.14

General Comments

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