INT313870

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Pah)
Pah (Mus musculus)
Pain Link Frequency Relevance Heat
beta blocker 3 39.36 Quite Low
Bioavailability 3 35.92 Quite Low
Calcium channel 6 15.88 Low Low
headache 9 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 198 100.00 Very High Very High Very High
Reprotox - General 2 15 100.00 Very High Very High Very High
Disease 51 89.00 High High
Coronary Heart Disease 3 76.48 Quite High
Hypertension 18 74.92 Quite High
Apnoea 3 73.52 Quite High
Obstructive Airway Disease 6 72.52 Quite High
Apoptosis 6 63.20 Quite High
Dyslipidemia /

Combined Dyslipidemia

3 56.32 Quite High
Hypoxia 12 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tadalafil is an orally administered PDE-5 inhibitor currently approved for treatment erectile dysfunction and PAH.
Negative_regulation (inhibitor) of PAH associated with reprotox - general 2 and pulmonary hypertension
1) Confidence 0.48 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 1.03 Pain Relevance 0
One study comparing sildenafil to inhaled NO (iNO) demonstrated comparable reductions in PA pressures and pulmonary vascular resistance (PVR), but increased cardiac index (CI) was seen only with sildenafil treatment, consistent with an inotropic effect.24 However, other investigators, examining load-independent measures of myocardial performance, found no changes in systolic or diastolic function with sildenafil treatment.25 Circulating endothelial progenitor cells are reduced in idiopathic PAH and congenital PAH, and treatment with sildenafil has been shown to increase these cells to levels consistently higher than other PAH therapies.26 Sildenafil also inhibits PDE-1, which is expressed in low levels in the pulmonary circulation under baseline conditions but is upregulated in the disease state.27 The clinical significance of these findings remains uncertain.
Negative_regulation (reduced) of PAH associated with pulmonary hypertension and disease
2) Confidence 0.48 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.62 Pain Relevance 0
One study comparing sildenafil to inhaled NO (iNO) demonstrated comparable reductions in PA pressures and pulmonary vascular resistance (PVR), but increased cardiac index (CI) was seen only with sildenafil treatment, consistent with an inotropic effect.24 However, other investigators, examining load-independent measures of myocardial performance, found no changes in systolic or diastolic function with sildenafil treatment.25 Circulating endothelial progenitor cells are reduced in idiopathic PAH and congenital PAH, and treatment with sildenafil has been shown to increase these cells to levels consistently higher than other PAH therapies.26 Sildenafil also inhibits PDE-1, which is expressed in low levels in the pulmonary circulation under baseline conditions but is upregulated in the disease state.27 The clinical significance of these findings remains uncertain.
Negative_regulation (reduced) of PAH associated with pulmonary hypertension and disease
3) Confidence 0.35 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.62 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox