INT313871

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a) oxidoreductase activity (Pah)
Anatomy Link Frequency
lung 1
Pde5a (Mus musculus)
Pah (Mus musculus)
Pain Link Frequency Relevance Heat
headache 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 66 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 90.12 High High
Hypoxia 4 82.44 Quite High
Reprotox - General 2 5 43.88 Quite Low
Cv General 4 Under Development 22 37.88 Quite Low
Hyperplasia 1 17.12 Low Low
Apoptosis 2 16.04 Low Low
Disease 17 5.44 Low Low
Hypertension 6 5.00 Very Low Very Low Very Low
Nonarteritic Anterior Ischaemic Optic Neuropathy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE-5 has been the focus for PAH because the PDE-5 enzyme is highly expressed in lung tissue compared to other vascular beds, with minimal expression in the systemic circulation.15,16 PDE-5 expression is upregulated in PAH, leading to increased metabolism of NO-derived cGMP.
PDE-5 Positive_regulation (upregulated) of PAH in lung associated with pulmonary hypertension
1) Confidence 0.49 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.97 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox