INT313885

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0

nucleus (XRCC1, PTEN) nucleoplasm (XRCC1) intracellular (XRCC1) enzyme binding (PTEN) lipid metabolic process (PTEN) cytoplasm (PTEN)

XRCC1 (Homo sapiens) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 3 47.92 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Renal Cancer 27 100.00 Disease 19 94.58 Cancer 8 93.08 Metastasis 4 74.20 Toxicity 10 48.96 Disease Progression 6 46.32 Pneumonia 12 5.00 Hypoxia 3 5.00 Stomatitis 3 5.00 Vomiting 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

A substantial study of 375 patients investigated the prognostic significance of mTOR pathway components in tumors obtained at nephrectomy, and observed adverse prognostic impact on disease-specific survival of pS6K, PTEN and Akt independent of stage.73 A small study further suggested that pS6K and possibly Akt were predictors of response to temsirolimus for advanced RCC.67,74 However an extension of the study20 of temsirolimus for poor prognosis advanced RCC did not find a correlation between PTEN and HIF-1?

RCC Neg (not) Spec (find) Positive_regulation (find) of Localization (correlation) of PTEN associated with cancer, renal cancer and disease

1) Confidence 0.00 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.65 Pain Relevance 0

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