INT313912

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat4) signal transduction (Stat4) nucleus (Stat4)
DNA binding (Stat4) cytoplasm (Stat4) signal transducer activity (Stat4)
Anatomy Link Frequency
nucleus 1
Stat4 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 92 81.60 Quite High
cytokine 12 73.68 Quite High
Etanercept 10 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
topical agent 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 3 86.80 High High
Psoriasis 103 81.60 Quite High
Necrosis 1 51.80 Quite High
Cancer 5 51.44 Quite High
Infection 6 32.72 Quite Low
Candida Infection 1 26.72 Quite Low
Adhesions 1 18.00 Low Low
Parakeratosis 1 11.04 Low Low
Erythema 1 7.28 Low Low
Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 and IL-23R chain are associated with intracellular proteins of the Janus kinase (Jak) family to induce downstream signaling, resulting in a sequence of phosphorylation processes activating signal transducer and activator of transcription (STAT) molecules, namely STAT1, STAT3, STAT4, and STAT5, which translocate into the nucleus where they bind DNA in the promoter region of target genes.24
Localization (translocate) of STAT4 in nucleus
1) Confidence 0.24 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

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