INT313915

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a, Il23a) extracellular region (Il12a, Il23a) cytoplasm (Il12a)
Anatomy Link Frequency
T cells 1
Il12a (Mus musculus)
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 39 99.76 Very High Very High Very High
psoriasis 94 61.40 Quite High
Multiple sclerosis 158 5.00 Very Low Very Low Very Low
Inflammation 33 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
Etanercept 10 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 105 75.64 Quite High
Necrosis 3 66.40 Quite High
Cancer 13 66.04 Quite High
Autoimmune Disease 49 58.40 Quite High
Adhesions 3 32.60 Quite Low
Parakeratosis 1 25.64 Quite Low
Demyelinating Disease 177 5.00 Very Low Very Low Very Low
Disease 88 5.00 Very Low Very Low Very Low
INFLAMMATION 40 5.00 Very Low Very Low Very Low
Central Nervous System Disease 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 is also part of the IL-12 receptor, IL-23R is unique to the IL-23 receptor complex (Figure 1).
IL-12 Binding (unique) of IL-23
1) Confidence 0.16 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.44 Pain Relevance 0.13
After this second signal, the T cells become activated, and APCs begin to secrete important cytokines, including IL-12 and IL-23, which bind to specific receptors on T cells and drive them to secrete different cytokines, such as IFN-?
IL-12 Binding (bind) of IL-23 in T cells associated with cytokine
2) Confidence 0.01 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0.17

General Comments

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