INT31394

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.38
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
hypothalamus 2
neutrophils 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 465 100.00 Very High Very High Very High
Endogenous opioid 47 100.00 Very High Very High Very High
IPN 101 99.92 Very High Very High Very High
imagery 20 99.92 Very High Very High Very High
narcan 49 99.82 Very High Very High Very High
agonist 94 99.76 Very High Very High Very High
chemokine 38 98.76 Very High Very High Very High
Enkephalin 217 95.92 Very High Very High Very High
Dynorphin 11 95.24 Very High Very High Very High
antinociception 47 93.68 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 101 99.92 Very High Very High Very High
Peritonitis 5 93.04 High High
Arthritis 16 89.76 High High
INFLAMMATION 260 89.40 High High
Injury 12 86.72 High High
Pain 182 86.60 High High
Reperfusion Injury 5 83.12 Quite High
Post Operative Pain 12 81.44 Quite High
Pneumococcal Infection 5 78.60 Quite High
Nociception 129 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Feedback inhibition of opioid peptide release in the hypothalamus of the rat.
Negative_regulation (inhibition) of Localization (release) of opioid peptide in hypothalamus associated with narcan and opioid
1) Confidence 0.39 Published 1987 Journal Neuroscience Section Title Doc Link 2891081 Disease Relevance 0 Pain Relevance 0.68
The release of these endogenous opioid receptor ligands is Ca2+ dependent and can be evoked by stimulation with high K+ (Manfredi et al 1995; Cabot et al 1997, 2001).
Negative_regulation (evoked) of Localization (release) of opioid receptor associated with endogenous opioid
2) Confidence 0.11 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.09 Pain Relevance 1.32
Both chelation of intracellular calcium by BAPTA/AM (Fig. 6F) as well as pretreatment with the PI3K inhibitors (LY294002 and wortmannin, Fig. 6H) prevented Mycobacterium butyricum-induced opioid peptide release.
Negative_regulation (prevented) of Localization (release) of opioid peptide associated with opioid
3) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.09 Pain Relevance 0.97
Opioid peptide release was blocked by intracellular calcium chelation as well as phosphoinositol-3-kinase inhibition.
Negative_regulation (blocked) of Localization (release) of Opioid peptide associated with opioid
4) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2657213 Disease Relevance 0.80 Pain Relevance 1.78
Blockade of FPR in vivo increased inflammatory pain by inhibiting tonic opioid peptide release
Negative_regulation (inhibiting) of Localization (release) of opioid peptide associated with ipn and opioid
5) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.10 Pain Relevance 0.98
CXCR1/2 agonist)-triggered opioid peptide release was less effectively blocked in rat compared to human neutrophils.
Negative_regulation (blocked) of Localization (release) of opioid peptide in neutrophils associated with agonist and opioid
6) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.70 Pain Relevance 1.15
Therefore it is conceivable that other receptors (e.g. chemokine receptors [62]) need to be blocked in addition to completely abolish opioid peptide secretion.
Negative_regulation (abolish) of Localization (secretion) of opioid peptide associated with chemokine and opioid
7) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.60 Pain Relevance 1.01

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox