INT314

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 15
Speculated 7
Reported most in Abstract
Documents 212
Total Number 219
Disease Relevance 66.68
Pain Relevance 55.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 134
kidney 7
blood 6
sympathetic 6
hypothalamus 4
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 231 100.00 Very High Very High Very High
Catecholamine 53 100.00 Very High Very High Very High
adenocard 23 100.00 Very High Very High Very High
Pain 15 100.00 Very High Very High Very High
Clonidine 98 99.98 Very High Very High Very High
Morphine 44 99.90 Very High Very High Very High
epidural 27 99.76 Very High Very High Very High
noradrenaline 17 99.74 Very High Very High Very High
acular 15 99.74 Very High Very High Very High
narcan 40 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 165 100.00 Very High Very High Very High
Heart Rate Under Development 68 100.00 Very High Very High Very High
Natriuresis 36 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Hypotension 63 99.90 Very High Very High Very High
Decapitation 16 99.90 Very High Very High Very High
Wilms Tumor 2 99.90 Very High Very High Very High
Obesity 51 99.88 Very High Very High Very High
Hypertension 394 99.84 Very High Very High Very High
Chronic Renal Failure 141 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such renin depleted rats were incapable of releasing renin (as judged by increase in plasma renin level) in response to severely hypotensive haemorrhage and had very blunted renin release responses to pentobarbital and urethane anesthesia (59 and 17% of normal respectively). 3.
Positive_regulation (increase) of renin in plasma associated with anesthesia, hypotension and cva
1) Confidence 0.70 Published 1981 Journal Pflugers Arch. Section Abstract Doc Link 7033921 Disease Relevance 0.44 Pain Relevance 0.24
Renin concentration and activity increased after pentobarbital anesthesia, while only renin activity was increased during ether anesthesia. 3.
Positive_regulation (increased) of renin associated with anesthesia
2) Confidence 0.70 Published 1983 Journal Comp Biochem Physiol A Comp Physiol Section Abstract Doc Link 6131777 Disease Relevance 0 Pain Relevance 0.38
The present results suggest that light ether anesthesia increases renin levels, except when blood samples are taken by decapitation, and that chronic catheterization and cardiac puncture are the choice blood extraction methods to evaluate the renin-angiotensin system in rats.
Neg (except) Positive_regulation (increases) of renin in blood associated with anesthesia and decapitation
3) Confidence 0.70 Published 1985 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 3906793 Disease Relevance 0.26 Pain Relevance 0.35
During 3% anaesthesia, plasma renin activity was markedly increased in the methyldopa group and decreased in the propranolol group.
Positive_regulation (increased) of renin in plasma
4) Confidence 0.70 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 636807 Disease Relevance 0.55 Pain Relevance 0.47
This anaesthesia-induced increase in plasma renin activity was not altered by guanethidine pretreatment.
Positive_regulation (increase) of renin in plasma associated with guanethidine
5) Confidence 0.70 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2699355 Disease Relevance 0.08 Pain Relevance 0.67
Yet, this difference was based on the impaired noradrenergic counterregulation in capsaicin-pretreated rats, because both groups showed identical responses to captopril following guanethidine-induced adrenergic blockade. (4) Plasma renin activity was increased by a factor of 2 following guanethidine treatment of awake animals.
Positive_regulation (increased) of renin in Plasma associated with guanethidine and qutenza
6) Confidence 0.70 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2699355 Disease Relevance 0.09 Pain Relevance 0.66
These results indicate that pentobarbital-induced drinking is not secondary to increased plasma renin activity and may suggest the involvement of central mechanisms in the drinking response.
Positive_regulation (increased) of plasma renin in plasma
7) Confidence 0.70 Published 1985 Journal Physiol. Behav. Section Abstract Doc Link 4041049 Disease Relevance 0 Pain Relevance 0.08
Activation of renin in normal plasma could also be induced at pH 7.4 by the addition of plasma from nephrectomized rats which had previously been dialyzed to pH 3.3.
Positive_regulation (Activation) of renin in plasma
8) Confidence 0.70 Published 1981 Journal Endocrinology Section Abstract Doc Link 7007027 Disease Relevance 0.06 Pain Relevance 0.15
Activation of rat plasma renin.
Positive_regulation (Activation) of renin in plasma
9) Confidence 0.70 Published 1981 Journal Endocrinology Section Title Doc Link 7007027 Disease Relevance 0.09 Pain Relevance 0.22
Acid dialysis (pH 3.3) of normal plasma resulted in a significant increase in renin concentration, confirming the presence of an inactive renin (prorenin) in this species.
Positive_regulation (increase) of renin in plasma
10) Confidence 0.70 Published 1981 Journal Endocrinology Section Abstract Doc Link 7007027 Disease Relevance 0.09 Pain Relevance 0.22
These results indicate that the activation of renin by acid dialysis is not directly mediated by acid conditions and confirm the existence of an endogenous plasma factor which, after acid dialysis, is capable of converting inactive to active renin.
Positive_regulation (activation) of renin in plasma
11) Confidence 0.70 Published 1981 Journal Endocrinology Section Abstract Doc Link 7007027 Disease Relevance 0 Pain Relevance 0.05
All of the agents studied induced dose- and time-related increases in serum renin activity when administered in anesthetic doses.
Positive_regulation (increases) of serum renin
12) Confidence 0.70 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1129282 Disease Relevance 0 Pain Relevance 0.18
Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection.
Positive_regulation (increase) of renin in plasma associated with serotonin and fluoxetine
13) Confidence 0.70 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.29
Saralasin is without effect on blood pressure and plasma renin in conscious normal rats and in spontaneously hypertensive rats, while it causes a transient 3 to 27 fold increase in plasma renin concentration in anaesthetized rats.
Positive_regulation (increase) of plasma renin in plasma associated with hypertension
14) Confidence 0.70 Published 1975 Journal Acta Pathol Microbiol Scand A Section Abstract Doc Link 170788 Disease Relevance 0.51 Pain Relevance 0
If such rats are only substituted with salt and not with DOCA, the effects of both blockers are in the form of severe hypotension and a permanent elevation of plasma renin.
Positive_regulation (elevation) of plasma renin in plasma associated with cv general 2 under development
15) Confidence 0.70 Published 1975 Journal Acta Pathol Microbiol Scand A Section Abstract Doc Link 170788 Disease Relevance 0.45 Pain Relevance 0
The increases in plasma renin activity were blocked by propranolol.
Positive_regulation (increases) of plasma renin in plasma
16) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24
After 10 min of immobilization, plasma renin activity was increased and VIP in plasma was unchanged.
Positive_regulation (increased) of plasma renin in plasma
17) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.17
Inactin anesthesia by itself increased plasma renin activity and this response was unaffected by propranolol and associated with a small decrease, rather than an increase in VIP in plasma.
Positive_regulation (increased) of plasma renin in plasma associated with anesthesia
18) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24
Previous work had shown that halothane and enflurane at 1 MAC and ketamine, 125 mg/kg, did not increase plasma renin activity (PRA) in the normal sodium-replete rat.
Neg (not) Positive_regulation (increase) of renin in plasma associated with ketamine and halothane
19) Confidence 0.70 Published 1978 Journal Anesthesiology Section Abstract Doc Link 666023 Disease Relevance 0 Pain Relevance 0.43
Renal cortical renin was elevated above control in the previously clipped left kidneys and suppressed below control in the right kidneys; on the average, there was a 30-fold difference in renins of the two kidneys.
Positive_regulation (elevated) of renin
20) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6379148 Disease Relevance 0 Pain Relevance 0.12

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