INT31403

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Context Info
Confidence 0.29
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 5.57
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AFM) extracellular region (AFM)
Anatomy Link Frequency
liver 1
AFM (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 191 99.98 Very High Very High Very High
rapifen 8 98.44 Very High Very High Very High
cva 38 93.08 High High
Opioid 1 71.32 Quite High
Analgesic 1 70.56 Quite High
Potency 1 49.44 Quite Low
Inflammation 7 22.56 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Liver Failure 98 100.00 Very High Very High Very High
Overdose 4 98.84 Very High Very High Very High
Sepsis 11 97.40 Very High Very High Very High
Liver Failure 40 97.12 Very High Very High Very High
Toxicity 20 96.32 Very High Very High Very High
Injury 102 95.08 Very High Very High Very High
Cv General 3 Under Development 37 93.08 High High
Necrosis 46 91.16 High High
Hepatitis B Virus Infection 4 89.76 High High
Hepatic Encephalopathy 28 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a linear increase in [ALF] produced by incremental infusions of alfentanil (r = 0.999).
Positive_regulation (increase) of ALF associated with rapifen
1) Confidence 0.29 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 2891324 Disease Relevance 0 Pain Relevance 0.40
Lee and colleagues [20] have reported similar outcomes with MARS in a series of 13 patients with drug-induced ALF: a statistically significant reduction in total bilirubin after a single MARS treatment (p < 0.006) but an overall mortality of 85% at 20 days.


Positive_regulation (induced) of ALF associated with acute liver failure
2) Confidence 0.08 Published 2007 Journal Crit Care Section Body Doc Link PMC2206413 Disease Relevance 0.98 Pain Relevance 0.08
Since the recognition of acetaminophen-induced ALF in the 1960s, acetaminophen overdose has become the commonest cause of liver failure in the United Kingdom [4].
Positive_regulation (induced) of ALF in liver associated with liver failure, paracetamol, acute liver failure and overdose
3) Confidence 0.04 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2856523 Disease Relevance 1.42 Pain Relevance 0.27
It may also reflect differences in the pathophysiology of drug-induced ALF as opposed to ischaemic models of ALF.
Positive_regulation (induced) of ALF associated with acute liver failure
4) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2856523 Disease Relevance 1.33 Pain Relevance 0.13
The major role for an ALF model is to provide a more controlled experimental environment than currently exists [18].
Positive_regulation (role) of ALF associated with acute liver failure
5) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2856523 Disease Relevance 1.29 Pain Relevance 0.09
Our aim was to develop a reproducible invasively-monitored porcine model of acetaminophen-induced ALF.


Positive_regulation (induced) of ALF associated with paracetamol and acute liver failure
6) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2856523 Disease Relevance 0.55 Pain Relevance 0.42

General Comments

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