INT314037

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) extracellular space (Plau) extracellular region (Plau)
kinase activity (Plau)
Anatomy Link Frequency
endothelial cells 2
THL (Mus musculus)
Plau (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 93 100.00 Very High Very High Very High
Potency 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 471 99.84 Very High Very High Very High
Metastasis 99 99.00 Very High Very High Very High
Breast Cancer 27 60.64 Quite High
Colon Cancer 24 48.32 Quite Low
Wound Healing 9 36.92 Quite Low
Recurrence 3 36.56 Quite Low
Lung Cancer 6 11.88 Low Low
Prostate Cancer 6 8.96 Low Low
Severe Combined Immunodeficiency 27 5.00 Very Low Very Low Very Low
Hypoxia 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study whether THL could inhibit the secretion of uPA in cancer cells, casein zymography assays were performed.
THL Negative_regulation (inhibit) of Localization (secretion) of uPA associated with cancer
1) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.55 Pain Relevance 0.37
We thus tested whether THL could inhibit the secretion of MMP-2, MMP-9, and uPA in cancer cells.
THL Negative_regulation (inhibit) of Localization (secretion) of uPA associated with cancer and metalloproteinase
2) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.95 Pain Relevance 0.40
We thus tested whether THL could inhibit the secretion of MMP-2 and uPA in endothelial cells.
THL Negative_regulation (inhibit) of Localization (secretion) of uPA in endothelial cells associated with metalloproteinase
3) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.14 Pain Relevance 0.22

General Comments

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