INT314038

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
THL (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 31 76.84 Quite High
Potency 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 157 99.52 Very High Very High Very High
Metastasis 33 95.76 Very High Very High Very High
Colon Cancer 8 93.68 High High
Recurrence 1 8.32 Low Low
Breast Cancer 9 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 9 5.00 Very Low Very Low Very Low
Hypoxia 7 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that THL could inhibit the phosphorylation of ERK1/2 but not that of AKT (Fig 2D) in CT-26 cancer cells, indicating that THL can inhibit the ERK signaling pathway but not the phosphatidylinositol-3-OH kinase (PI3K)/AKT signaling pathway.


THL Negative_regulation (inhibit) of PI3K associated with cancer
1) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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