INT314042

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.97
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
endothelial cells 4
extracellular matrix 2
THL (Mus musculus)
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 93 100.00 Very High Very High Very High
Potency 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 471 100.00 Very High Very High Very High
Metastasis 99 99.56 Very High Very High Very High
Colon Cancer 24 94.32 High High
Severe Combined Immunodeficiency 27 77.88 Quite High
Hypoxia 21 55.52 Quite High
Breast Cancer 27 48.52 Quite Low
Recurrence 3 24.44 Low Low
Disease 12 22.76 Low Low
Apoptosis 21 14.12 Low Low
Injury 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Firstly, THL could inhibit, in cancer cells, the expression and secretion of MMP-2, MMP-9, and uPA (Fig 2A, C), which involve in degradation of extracellular matrix and play important roles in cancer cell migration and invasion [5,6,63].
THL Negative_regulation (inhibit) of Gene_expression (expression) of MMP-2 in extracellular matrix associated with cancer and metalloproteinase
1) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.86 Pain Relevance 0.14
With regard to the direct inhibitory effect on endothelial cells, we have found that THL could inhibit the expression of MMP-2 (Fig 4C) and uPA (Fig 4D) in endothelial cells.
THL Negative_regulation (inhibit) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
2) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.04 Pain Relevance 0.05
We thus tested whether THL could inhibit VEGF-induced MMP-2 expression in endothelial cells.
THL Negative_regulation (inhibit) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
3) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.07 Pain Relevance 0.23

General Comments

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